大家好,今天给大家推荐发表在PNAS上的文章 'Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses'。文章的通讯作者是中南大学的Prof. Jing Liu(主要研究造血干细胞发育...
2019年6月13日,来自美国加利福尼亚大学的Chien-Hsiang Hsu、Steven J. Altschuler和Lani F. Wu在Cell上发表题为Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy的文章,在单细胞水平清晰阐明了 “非致死...
High levels of p21 then result in RB-E2F complex formation and downregulation of a large number of cell cycle genes. Thus, p53-dependent transcriptional repression is indirect. The reduced expression of the many regulators leads to cell cycle arrest. Examination of the p53-p21-RB targets and ...
Mutational analysis of p21 suggested that mechanisms other than cell cycle inhibition, PCNA binding, and derepression of p300/CBP repression domain CRD1 underlie the transcriptional effects. These results suggest that p21 may have a role in transcription rather than in cell cycle regulation in ...
Wu在Cell上发表题为Patterns of Early p21 Dynamics Determine Proliferation-Senescence CellFate after Chemotherapy的文章,在单细胞水平清晰阐明了 “非致死剂量化疗”早期p21的动力学状态在细胞最终增殖或衰老的命运抉择过程中的因果关系,为癌症化疗策略的优化提供了坚实有效的基础。 研究者们首先建立了一个实验体系,...
Garcia-Tumon I,Ricote M,Ruiz A, et al.Cell cycle control related proteins (p53, p21, and Rb) and transforming growth factor beta (TGFbeta) in benign and carcinomatous (in situ and infiltrating) human breast: implications in malignant transformations[].Cancer Investigation.2006...
orchestrates G 1 to S cell cycle transition in colon eaneer cells IJ].Beijing Da Xue Xue Bao,2003,18;35( 1) :50—53. 2 J aschke B ,Milz S ,Vogeser M,et a1.I~ cal cyclin—dependent ki- nase inhibition by fl avopirid ol inhibits coro nary artery smoo th ...
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21. Nature 375: 159–161.Luo Y, Hurwitz J, Massague J: Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature 1995, 375: 159–161....
The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The main, well-known function of p21 is to arrest cell cycle progression by inhibiting the activity of cyclin-dependent...
是一类细胞周期疾病(cellcycledisease)”的观点。研究表明,细胞周期素(cyclins), 依赖周期素的激酶(CDK)和CDK抑制蛋白(CDKIP)是细胞生长发育过程中细胞周 期调控的主要因子,这些因子在细胞周期中调控失常,会导致细胞生长失控和分 化受阻而产生肿瘤。其中正调节因子有细胞周期素依赖性激酶4(CDK4)[31、细胞 周期素D...