探讨博来霉素(bleomycin, BLM) 损伤所致小鼠肺纤维化发病过程中肺泡巨噬细胞的细胞周期抑制因子p21 (cell cycle inhibitor p21, p21) 蛋白表达及其对巨噬细胞活化的调节作用。免疫荧光染色法检测肺纤维化组织中肺泡巨噬细胞中CD206 的表达; RT-PCR (reverse tranion-polymerase chain reaction) 法检测巨噬细胞活化标...
Cell cycle inhibitor p21/WAF1/CIP1 as a cofactor of MITF expression in melanoma cells. Pigment Cell Melanoma Res. 2010; 23 (2):238–251.Sestakova B, Ondrusova L, Vachtenheim J (2010) Cell cycle inhibitor p21/ WAF1/CIP1 as a cofactor of MITF expression in melanoma cells. Pigment ...
大家好,今天给大家推荐发表在PNAS上的文章 'Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses'。文章的通讯作者是中南大学的Prof. Jing Liu(主要研究造血干细胞发育...
p21高细胞存在于所有10种细胞类型中,并且在巨噬细胞和肥大细胞中更为丰富(图4C)。使用Seurat的CellCycleScoring功能进行细胞周期注释,作者发现p21高表达细胞在G2/M期包含的细胞较少(图4D和4E),这些细胞预计会增殖并随着衰老而减少。此外,作者发现p21高细胞的组成在老年小鼠的不同器官中差异很大。在衰老的肌肉中,p21...
Mutational analysis of p21 suggested that mechanisms other than cell cycle inhibition, PCNA binding, and derepression of p300/CBP repression domain CRD1 underlie the transcriptional effects. These results suggest that p21 may have a role in transcription rather than in cell cycle regulation in ...
2. Ryl, T., Kuchen, E.E., Bell, E., Shao, C., Florez, A.F., Monke, G., Gogolin, S., Friedrich, M., Lamprecht, F., Westermann, F., et al. (2017). Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictat...
Merkel cell carcinoma (MCC) is an aggressive dermal tumour of neuroendocrine origin with poor prognosis. The role of cell cycle-regulatory proteins (p53/p21/p27) in MCC pathogenesis and their prognostic importance were evaluated. Twenty-four primary MCC specimens with corresponding clinical data were...
2. Ryl, T., Kuchen, E.E., Bell, E., Shao, C., Florez, A.F., Monke, G., Gogolin, S., Friedrich, M., Lamprecht, F., Westermann, F., et al. (2017). Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug.Cell Syst.5,...
The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The main, well-known function of p21 is to arrest cell cycle progression by inhibiting the activity of cyclin-dependent...
题目:Cell cycle regulation: p53-p21-RB signaling 译名:细胞周期调控:p53-p21-Rb信号转导 期刊:Cell Death & Differentiation IF:15.828 发表时间:2022.3.31 通讯作者单位:莱比锡大学 DOI号:https://doi.org/10.1038/s41418-022-00988-z Highlight