CNPase contains an N-terminal domain very distantly related to P-loop containing nucleoside triphosphate hydrolases [7,8] and a C-terminal phosphodiesterase... J Lee,M Gravel,E Gao,... - 《Journal of Biological Chemistry》 被引量: 249发表: 2001年 Crystal structures of HINT demonstrate that ...
The tetraacyldisaccharide 4'-kinase (LpxK) of the diverse P-loopcontaining nucleoside triphosphate hydrolase superfamily catalyzes the sixth step in the biosynthetic pathway of lipid A, and is the only known P-loop kinase to act upon a lipid substrate at the membrane. Here, we report the ...
T he phosphate-binding loop (P-loop) is a conserved sequence motif found in the superfamily of P-loop nucleoside triphosphate hydrolases (P-loop NTPases)1. The P-loop, also known as the Walker A motif, has the consensus sequence GxxxxGK(S/T) and contributes to the binding of ...
Gorbalenya AE, Koonin EV, Donchenko AP, Blinov VM: A novel superfamily of nucleoside triphosphate-binding motif containing proteins which are probably involved in duplex unwinding in DNA and RNA replication and recombination. FEBS Lett. 1988, 235: 16-24. 10.1016/0014-5793(88)81226-2. Article ...
Both the recombination and coprotease functions require a nucleoside triphosphate (NTP) cofactor; however, coprotease activity requires only NTP binding (9, 10), whereas completion of DNA strand exchange reactions depends on NTP hydrolysis as well (reviewed in Ref. 11). The ATP binding site of ...
The P-loop containing nucleoside triphosphate hydrolase fold includes this motif, and is one of the most ancient folds and by far the most abundant (10-18% of all ORFs). In the present work, the sequence of a primordial β-Ploop-α motif was inferred. We further showed that this β-...
The tetraacyldisaccharide 4′-kinase (LpxK) of the diverse P-loop-containing nucleoside triphosphate hydrolase superfamily catalyzes the sixth step in the biosynthetic pathway of lipid A, and is the only known P-loop kinase to act upon a lipid substrate at the membrane. Here, we report the ...
The structures of fully fledged catalytic sites of P-loop NTPases were selected among those PDB entries that matched the following criteria: (1) the entry is assigned to the InterPro record IPR027417 “P-loop containing nucleoside triphosphate hydrolase”; (2) contains an ATP/GTP molecule, or...
The structures of fully fledged catalytic sites of P-loop NTPases were selected among those PDB entries that matched the following criteria: (1) the entry is assigned to the InterPro record IPR027417 "P-loop containing nucleoside triphosphate hydrolase"; (2) contains an ATP/GTP molecule, or ...