enzyme helps to maintain asymmetry by translocating only aminophsopholipids from the outer to the inter leaflet; we have cloned the gene encoding an ATPase thought to be the aminophospholipid translocase and discovered that it is a member of a previously unrecognized class of P-type ATPases. At...
Ion Motive ATPases: P‐type ATPasespumpsATPaseP-typeRegulation of ions such as calcium, sodium and potassium ions is very important for cell life. One of ion-regulating enzymes is classified as ion motive adenosine triphosphatase ( ATPase ). Ion motive ATPases exchange two different ions ...
All P-type ATPases share a common topology with a transmembrane and three cytoplasmic domains and their transport cycle follows a general scheme — the Post-Albers-cycle. Recently, P-type ATPase research has been advanced most significantly by the technological advancements in cryo-EM analysis, ...
widely developed in the literature, is largely based on the ability to linearize the equation and apply linear regression to experimental data. However, certain systems, such as P-type ATPases, present mechanisms that do not
Table 1. P-type ATPases. ClassSubstrateDisease associatedGenesRemarks P1-ATPases P1A K+ – Bacterial Kdp-ATPases; smallest P-type ATPase P1B Cu+, Ag+, Cu2 +, Zn2 +, Pb2 +, Cd2 +, Co2 + – ATP7A, ATP7B Omnipresent. Helps in metal homeostasis, metal detoxification and metal re...
P-type ATPases use the energy from ATP hydrolysis to pump ions across the cell membrane against a concentration gradient. They form a large family of ubiquitous membrane proteins, and carry out many essential processes, such as generating the membrane potential or removing toxic ions from cells....
Meade, Identification of surface-membrane P-type ATPases resembling fungal K(+)- and Na(+)-ATPases, in Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani, Ann. Trop. Med. Parasitol. 97 (2003) 351-366.Stiles JK, Kucerova Z, Sarfo B, Meade CA, Thompson W, Shah P, Xue L,...
G. Evolution of substrate specificities in the P-type ATPase superfamily. J. Mol. Evol. 46, 84–101 (1998). A thorough analysis of the sequence homology among P-type ATPases. CAS PubMed Google Scholar Bult, C. J. et al. Complete genome sequence of the methanogenic archaeon, ...
Ionic leakage underlies a gain-of- function effect of dominant disease mutations affecting diverse P-type ATPases. Nat Genet 2014; 46: 144-51.Kaneko, M., Desai, B. S. & Cook, B. Ionic leakage underlies a gain-of-function effect of dominant disease mutations affecting diverse P-type AT...
Cation-transporting P-type ATPases show a high degree of structural and functional homology. Nevertheless, for many members of this large family, the molecular mechanism of transport is unclear; namely, whether transport is electrogenic or not and if countertransport is involved remains to be estab...