Pleban K and Ecker GF (2005) Inhibitors of p-glycoprotein--lead identification and optimisation. Mini Rev Med Chem 5:153-63.Pleban K, Ecker GF. Inhibitors of p-glycoprotein--lead identification and optimisation. Mini Rev Med Chem. 2005;5:153-63....
The results presented in Figs1–4suggested that P-glycoprotein inhibition leads to enhanced therapeutic efficacies. To determine whether the P-gp inhibitors caused increased cellular retention of P-gp transport substrates, we assessed the accumulation of a known P-gp substrate, calcein AM. Calcein AM...
P-glycoprotein inhibitorsbioavailabilitymultidrug resistanceocular diseaseIntroduction: P-glycoprotein is a complex ATP-ase transporter involved in physiological and pathological functions. In particular, it is involved in the onset of multidrug resistance in cancer, in ocular disease, Chronic Rhinosinusitis, ...
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However, the role of this transporter in drug–drug interactions is still poorly studied even though a lot of P-glycoprotein substrates and P-glycoprotein inhibitors are identified among drugs of standard usage. On one hand, Pgp is distributed within a lot of organs and tissues implicated in ...
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The overexpression of the ATP binding cassette (ABC) transporter, P-glycoprotein (P-gp), which significantly increases the efflux of certain anticancer drugs from tumor cells, produces MDR. Therefore, inhibition of P-gp may represent a viable therapeutic strategy to overcome cancer MDR. Over the ...
It provides first-hand information to the scientists working in the field of drug discovery to further synthesise and discover new P-gp inhibitors with less toxicity and more efficacies. Keywords: P-glycoprotein (P-gp); multi drug resistance (MDR); ABC transporters; P-gp inhibitors; chemotherapy...
Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses. Biochem. Pharmacol. 2016, 104, 42–51. [CrossRef] [PubMed] 19. Ayrton, A.; Morgan, P. Role of transport proteins in drug absorption, distribution and...
Evidence for enhanced intestinal absorption of digoxin by p- glycoprotein inhibitors. Trop J Pharm Res. 2012;11(6):939-945.Valizadeh H, Mehtari M, Zakeri-Milani P. Evidence for enhan- ced intestinal absorption of digoxin by P-glycoprotein inhibi- tors. Trop J Pharm Res. 2012; 11: 939-...