Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEP-gpinhibitor26Cat.No.:HY-168186CASNo.:3055666-79-7分⼦式:C₃₃H₃₄N₄O₄分⼦量:550.65作⽤靶点:P-glycoprotein作⽤通路:MembraneTransporter/IonChannel储存⽅式:Pleasestoretheproductundertherecommendedcondition...
Since then, P-gp inhibitors have been intensively studied as potential MDR reversers. Initially, drugs to reverse MDR were not specifically developed for inhibiting P-gp; in fact, they had other pharmacological properties, as well as a relatively low affinity for MDR transporters. An example of ...
7. Juliano, R.L. and V. Ling, A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta, 1976. 455(1): p. 152-62. 8. Raghava, S. and P.K. Lakshmi, Overview of P-glycoprotein ...
Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. J Med Chem. 2017 Apr 27;60(8):3289-3302. 关键词 P-gp ...
(12)represent the second-generation P-gp inhibitors. They have relatively high potency and P-gp selectivity, and low toxicity; however, they also significantly inhibit certain cytochrome P450 enzymes, thereby increasing the likelihood...
P-gp Inhibitors on signaling pathway are available at Adooq Bioscience. Check P-gp pathway , inhibitors reviews and assay information.
[1]. Qiu Q, et al. Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. J Med Chem. 2017 Apr 27;60(8):3289...
研究结果以“Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells”为题发表在1月17日的《Scientific Reports》上。 研究人员用分子抑制剂和传统化疗药物联合的方法来治疗侵略性微小肿瘤, 这些化疗药物本身对耐药性肿瘤无效 。Vogel说:“所有细胞都有自己的...
Recently, computational models have gained importance to discover new inhibitors. In the present study, we aimed to explore the various compounds of Passiflora species as P-gp inhibitor. P-gp protein was docked with the active substrate and inhibitor, respectively, including tamoxifen and verapamil....
(12)represent the second-generation P-gp inhibitors. They have relatively high potency and P-gp selectivity, and low toxicity; however, they also significantly inhibit certain cytochrome P450 enzymes, thereby increasing the likelihood of clinically problematic drug–drug interactions. The potency and ...