Ling, V (1995) P-glycoprotein: its role in drug resistance. Am J Med 99: pp. 31S-34SLing V. P-glycoprotein: its role in drug resistance. Am J Med 1995; 99: 315-45.Ling, V. P-glycoprotcin:its role in drug resistance.Am. J. Med., 99(Suppl): 3lSa€"34S, functions ...
别 名 P-Glycoprotein; Multi Drug Resistance Associated Protein, ABCB1; ATP-binding cassette sub-family B (MDR/TAP), member 1; ABC20; CD243; CD243 antigen; CLCS; Multidrug resistance protein 1; P glycoprotein 1; p-GP; gp170; P gp; PGY1; MDR1_HUMAN. 浓 度 1mg/1ml 规 格 0.1ml/...
Drugs as P-glycoprotein substrates, inhibitors, and inducers: Drug Metabolism Reviews: Vol 34, No 1-2 MDR1 (once P-glycoprotein, now referred to as ABCB1) plays a role as a blood-brain barrier, preventing drug absorption into the brain, and is known to conf... Richard,B.,Kim - 《Dr...
It appears that the substrates, inhibitors, or inducers are nonselective for various P-gps. P-glycoprotein should exhibit saturation/nonlinear kinetics; at or near saturation concentrations, an increase in drug absorption can result in a two- to threefold increase in plasma drug concentration. ...
P-glycoprotein (P-gp) on the apical membranes of epithelial cells is known as a drug efflux pump. However, unclear is its integral quantitative role in the overall epithelial drug transfer, which also involves distinct diffusion processes in parallel and sequence. We used a simple three-compartme...
Overexpression of ATP-binding cassette (ABC) transporters is often linked to multidrug resistance (MDR) in cancer chemotherapies. P-glycoprotein (P-gp) is one of the best studied drug transporters associated with MDR. There are currently no approved drug
IMPORTANCE OF THE FIELD: P-glycoprotein (P-gp) is the most characterized drug transporter in terms of its clinical relevance for pharmacokinetic disposition and interaction with other medicines. Clinically significant P-gp related drug interactions appear restricted to digoxin. P-gp may act as a ...
Application of permeability-limited physiologically-based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P-glycoprotein-mediated ef... A prerequisite for the prediction of the magnitude of P-glycoprotein (P-gp)-mediated drug–drug interactions between digoxin and P-gp inhibitors (e...
Implications of Drug Pumps (P-Glycoprotein) for Toxin Researchdoi:10.3109/15569548709053862W.CollegeT.CollegeShierCollegeInformaworldJournal of Toxicology: Toxin Reviews
These results suggest that P-glycoprotein-mediated drug efflux possibly did not play a primary role in the drug resistance of K562/Dox cells. 展开 关键词: DRUG RESISTANCE P-GLYCOPROTEIN DOXORUBICIN CELLULAR PHARMACOKINETICS DOI: 10.1159/000239359 ...