oxidative stressCCN1skin agingfibroblastsECMcollagenReactive oxygen species (ROS) is an important pathogenic factor involved in human aging. Human skin is a primary target of oxidative stress from ROS generated from both extrinsic and intrinsic sources, like ultraviolet irradiation (UV) and endogenous ...
Oxidative stress can cause skin wrinkling and is known to be associated with skin diseases in humans. It has been suggested to play a role in the pathogenesis of human skin cancers1. Reactive oxygen species (ROS) are involved in the pathogenesis of several allergic and inflammatory skin diseases...
Excessive oxidative stress may lead to skin problems, especially aging4 and skin cancer5. Recently, oxidative stress has also come to light as a possible mechanism in autoimmune skin diseases6, inflammatory skin diseases7, and pigmentation skin disorders, such as vitiligo8,9,10. Theoretically, ...
Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging and even more for extrinsic aging. Although the results ... R Mark,B Johannes,S Maria,... - 《Biomolecules》 被引量: 122发表: 2015年 Oxidative Stress in Aging Human Skin Oxidative stress...
Introductory sections cover oxygen, free radicals (ROS), oxidative stress, antioxidants, human skin aging, cellular/molecular ROS events in skin, steroid enzymes/receptors/hormonal actions and genetic factors in aging skin. The main focus of this review covers the characteristics of equol (...
Cells from patients with the autosomal recessive disorder ataxia-telangiectasia (A-T) display accelerated telomere shortening upon culture in vitro. It has... T Andrei,PM Lansdorp - 《Human Molecular Genetics》 被引量: 261发表: 2003年 Oxidative stress and reduced antioxidant defenses in peripheral ...
The imbalance of pro-oxidants and antioxidants leads to an age-related accumulation of oxidative damage in macromolecules, resulting in a progressive loss in function and aging [1]. Over the past three decades, the Oxidative Stress Theory of Aging has become one of the most popular theories to...
Environmental Pollutants-Induced Oxidative Stress: A Role for Antioxidants in Health Promotion and Aging Prevention The book offers a comprehensive review of current research regarding the influences of environmental factors involved in human health and ageing. Many environmental compounds promote excessive ...
Rinnerthaler, M., Bischof, J., Streubel, M. K., Trost, A. & Richter, K. Oxidative stress in aging human skin.Biomolecules.5, 545–589 (2015). ArticleCASGoogle Scholar Venza, M.et al. Cellular Mechanisms of Oxidative Stress and Action in Melanoma.Oxid Med Cell Longev.2015, 481782 (...
In conclusion, skin aging processes may involve ROS-induced protein dysfunction due to disulfide bond formation, and H2 can protect oxidation of this process. The oxidative stress theory of aging suggests that aging results from the accumulation of aberrant proteins in the cytosol, chemical damage ...