Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions. The purpose of...
Among other mechanisms, oxidative stress has been postulated to play an important role in the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential components in pathological pathways which are thought to drive multiple age-related diseases. Nonetheless, results from stu...
Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace The rapid expansion of the elderly population has led to the recent epidemic of age-related diseases, including increased incidence and mortality of chronic and acute lung diseases. Numerous ...
In the absence of positive oxidative stress, however, these basal level modifications may have no apparent protective effects owing to their low abundance. Herein to demonstrate the role of positive oxidative stress in aging and aging-associated diseases, I would like to present a few selected ...
Aging is a physiologic state in which a progressive decline of organ functions is accompanied with the development of age-related diseases. The causes of aging remain unknown, probably being related to a multifactorial process. To date, the free radical and mitochondrial theories seem to be the ...
Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases. Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, age-related macular degeneration (AMD), and Alzheimer...
Oxidative stress has been implicated in the progression of a number of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis(ALS). These diseases are characterized by extensive oxidative damage to lipids, proteins and DNA. This dama...
Mounting evidence suggests that normal age-related functional decline and diseases of aging arise at least in part from the accumulation of molecular damage due to oxidative stress and inflammation (5,6 for reviews). The oxidative stress (OS) theory of aging proposes that the slow and steady ...
For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging. Our view of oxidative stress has been largely “superoxide-centric”, as we focused on the pathological sources ...
Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in preclini