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Among other mechanisms, oxidative stress has been postulated to play an important role in the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential components in pathological pathways which are thought to drive multiple age-related diseases. Nonetheless, results from stu...
Various environmental factors such as smoking and dietary habits are known to increase the risk for many diseases associated with aging. These factors link oxidative stress, cellular senescence, and microbial assault to the host. Oxidative stress has been associated with many aging disorders including ...
Ageing is a process characterized by a progressive decline in cellular function, organismal fitness and increased risk of age-related diseases and death. Several hundred theories have attempted to explain this phenomenon. One of the most popular is the 'oxidative stress theory', originally termed the...
which can be enhanced by smoking and dietary habits, is known to increase the risk for many diseases associated with aging. Systemic oxidative stress not only results in accumulation of reactive oxygen species (ROS), but also damages DNA or modifies DNA structures at an epigenetic level, altering...
Mounting evidence suggests that normal age-related functional decline and diseases of aging arise at least in part from the accumulation of molecular damage due to oxidative stress and inflammation (5,6 for reviews). The oxidative stress (OS) theory of aging proposes that the slow and steady ...
Inflammation, Oxidative Stress and Age-Related Diseasedraws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer...
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(a) In vitro exposure of enzymes to ROS elicits changes in catalytic activity, heat stability, and proteolytic susceptibility similar to those that occur during aging (27, 28, 29, 30). (b) Brief exposure of animals to oxidative stress leads to alterations in enzymes similar to that ...
Emerging evidence suggests that accumulated oxidative stress may be one of the key mechanisms causing cognitive aging and neurodegenerative diseases such as Alzheimer's disease (AD). Here, we synthesize the current literature on the effect of neuronal oxidative stress on mitochondrial dysfunction, DNA ...