The oxidative stress theory of aging postulates that age-associated reductions in physiologic functions are caused by a slow steady accumulation of oxidative damage to macromolecules, which increases with age and which is associated with life expectancy of organisms. A corollary is that the rate of ...
In the last years, genetically modified animals were obtained to test the oxidative stress theory of aging. Some studies found that the overexpression of antioxidant enzymes extends lifespan, corroborating the theory, but other works put it in doubt by showing that increased ROS levels increase ...
The oxidative stress (OS) theory of aging proposes that the slow and steady accumulation of macromolecular damage from reactive oxygen species (ROS) eventually leads to the functional impairment or irreversible loss of terminally differentiated cells7. Related theories include the mitochondrial theory of...
SummaryThe oxidative stress theory of aging has become increasingly accepted as playing a role in the aging process, based primarily on a substantial accum... Tamara,R.,Golden,... - 《Aging Cell》 被引量: 739发表: 2002年 Oxidative stress and aging in Caenorhabditis elegans Much attention has...
Reflections on the Theories of Aging, of Oxidative Stress, and of Science in General. Is It Time to Abandon the Free Radical (Oxidative Stress) Theory of A... S. I. Liochev, "Reflections on the theories of aging, of oxidative stress, and of science in general. is it time to abandon...
This state-of-the-art book discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). In addition...
Testing Predictions of the Oxidative Stress Hypothesis of Aging Using a Novel Invertebrate Model of Longevity: The Giant Clam (Tridacna Derasa).EvolutionMolluscOxidativestresstheory.SenescenceBivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily ...
This book brings together some of the leading researchers in the actively investigated field of oxidative stress, an area of study which is of importance to human health and disease. It examines oxidative stress in a variety of models, at rest and after exercise, in young and old. Key concep...
The free radical theory of aging proposes that the impairment in physiological performance associated with aging is caused by the detrimental effects of oxygen free radicals. This is interesting because it provides us with a theoretical framework to understand aging and because it suggests a rationale...
Over the past three decades, the Oxidative Stress Theory of Aging has become one of the most popular theories to explain the biological/molecular mechanism underlying aging because several lines of evidence support the theory. First, the levels of oxidative damage to lipid, DNA, and protein have...