autophagylysosomal storage diseaseoxidative stress neuromuscularMany neurodegenerative conditions have oxidative stress burdens where levels of reactive oxygen species (ROS) exceed the antioxidant capacity of the neuron. ROS can induce wide-ranging damage in a cell and this is prevented by the activation ...
Autophagy is a catabolic process aimed at recycling cellular components and damaged organelles in response to diverse conditions of stress, such as nutrient deprivation, viral infection and genotoxic stress. A growing amount of evidence in recent years argues for oxidative stress acting as the convergin...
Autophagy Oxidative stress Atherosclerosis Cardiomyopathy Hypertension Heart failure 1. Introduction Autophagy, first coined by Belgian biochemist Christian de Duve in 1966 [1], is characterized by the lysosome-dependent degradation of cytoplasm and damaged organelles such as mitochondria, endoplasmic reticulum...
Many neurodegenerative conditions have oxidative stress burdens where levels of reactive oxygen species (ROS) exceed the antioxidant capacity of the neuron. ROS can induce wide-ranging damage in a cell and this is prevented by the activation of antioxidant responses including autophagy. Jun-kinase (JN...
Forum Review: Oxidative stress and autophagyKiffinBandyopadhyayCuervo
Finally, we detected whether ROS induced by aldosterone could cause ER stress and autophagy in cultured podocytes. These results indicate that the key components of ROS, ER stress, and autophagy signaling pathways are potential therapeutic targets for glomerular diseases. MATERIALS AND METHODS Reagents ...
Activation of JNK is necessary for the acute alcohol-induced steatosis. CYP2E1-derived oxidant stress plays a key role in the lipid accumulation and the activation of JNK. A decrease in autophagy is associated with the alcohol-induced steatosis.关键词:...
In heart failure (HF), mitochondrial quality control and autophagy are progressively impaired, but the role of oxidative stress in this process and its underlying mechanism remain to be defined. By degrading norepinephrine and serotonin, the mitochondrial enzyme, monoamine oxidase-A (MAO-A), is a...
Ferroptosis is an iron-dependent cell death process, which is distinct from other forms of programmed cell death such as apoptosis, necrosis, and autophagy (Hirschhorn and Stockwell, 2019). Ferroptotic cell death is marked by the presence of lipid species derived from peroxidation. Extensive ...
and loss of physiological functions, including the capability to control the cellular redox and its regulatory function on signal transduction andgene transcriptionpathways important to adapt to endogenous and exogenous stimuli, to control the cellular metabolism, as well as cell death and autophagy ...