1995. Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues. Br. J. Haematol. 91:927.Du¨ rkop, H., Latza, U., Himmelreich, P., Stein, H. (1995) Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues. Br. J. Haematol. 91, 927...
OX40 expression in neutrophils promotes hepatic ischemia/reperfusion injury. JCI Insight. 2019;4. Nuebling T, Schumacher CE, Hofmann M, Hagelstein I, Schmiedel BJ, Maurer S, et al. The immune checkpoint modulator OX40 and its ligand OX40L in NK-cell immunosurveillance and acute myeloid ...
Here, we show that Survivin expression in mature antigen-responding CD4 T cells is regulated after PKB(Akt) activation from OX40 and that sustained Survivin expression is required to maintain T cell proliferation while at the same time antagonizing apoptosis. We show that Survivin regulates G1/S...
A ligand was cloned for murine OX40, a member of the TNF receptor family, using a T cell lymphoma cDNA library. The ligand (muOX40L) is a type II membrane protein with significant identity to human gp34 (gp34), a protein whose expression on HTLV-1-infected human leukemic T cells is...
OX-40在调节CD4和CD8 T细胞克隆扩增中起主要作用。它向抗原反应性幼稚T细胞提供共刺激信号以延长增殖,并增加几种细胞因子的产生。这由OX-40敲除小鼠证明,其在免疫后产生较少的初级效应CD4 T细胞。此外,用OX-40的激动剂抗体进行的体内治疗已经显示出强烈地增强了抗原特异性效应T细胞的产生,并防止了T细胞耐受性的诱导...
Therapeutic targeting miR130b counteracts diffuse large B-cell lymphoma progression via OX40/OX40L-mediated interaction with Th17 cells miR130b downregulated tumor OX40L expression by directly targeting IFNAR1/p-STAT1 axis,recruiting Th17 cells via OX40/OX40L interaction,thereby promoting ... R ...
CD137, another TNFRSF member has been shown to enhance the anti-tumour activity of NK cells in various malignancies. Here, we examine the expression and function of CD134 on human and mouse NK cells in B-cell lymphoma. CD134 was transiently upregulated upon activation of NK cells in both...
in vivo OX40 activation Kurche, J. S., et al. (2012). “Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression.” J Immunol 188(2): 585-593 ...
Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels. OX40 has no effect on the proliferative abilities of CD4+ cells for the first three days, however after this time proliferation begins to slow and ...
Bell et al., “OX40 signaling in head and neck squamous cell carcinoma: Overcoming immunosuppression in the tumor microenvironment,” Oral Oncology, 2016, pp. 1-10, vol. 52. Ramser et al., “High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy...