The expression of OX40, OX40L and NFATc1 in lymphocytes was measured by Real Time PCR (RT-PCR) and flow cytometry (FCM), respectively. The presence of NFATc1 in the atherosclerotic plaque was detected by immunohistochemistry. The level of IL-4 was measured by ELISA. We found that the ...
Furthermore, OX40 expression on T cells was positively associated with obesity in humans, suggesting that our findings are clinically relevant. In summary, our study revealed that OX40 in CD4(+) T cells is crucial for adipose tissue inflammation and IR development. Therefore, the OX40 signaling...
Survivin allows effector T cells to accumulate in large numbers, but Bcl-2 family proteins are required for T cell survival after the phase of active division. Thus, sustained Survivin expression from costimulatory signaling maintains T cell division over time and regulates the extent of clonal ...
OX40 expression in neutrophils promotes hepatic ischemia/reperfusion injury. JCI Insight. 2019;4. Nuebling T, Schumacher CE, Hofmann M, Hagelstein I, Schmiedel BJ, Maurer S, et al. The immune checkpoint modulator OX40 and its ligand OX40L in NK-cell immunosurveillance and acute myeloid ...
The proportion of cTfh cells in the peripheral blood and the expression of OX40 on the surface of cTfh cells were detected. T-test or χ 2 test was used to compare the indexes between the two groups. Pearson correlation analysis was used to analyze the correlation between HOMA-IR and ...
OX40 expression on CD4 +CD25 +CD127 low Treg cells in peripheral blood samples in the two groups were analyzed by immunofluorescent labeling and flow cytometry. Correlations of OX40 +Treg cell percentage with National Institute of Health stroke scale (NIHSS) scores, ischemic penumbra volume, ...
inflammation and the exacerbation of the disease are not clear.Also their correlations with airway inflammation and clinical symptoms and severity of asthma remains to be clarified.This research project studied the expression level OX40/OX40L in the peripheral blood and analyzed the concentration of ...
(1). OX40L is expressed on activated antigen presenting cells such as B cells, macrophages, dendritic cells, and on endothelial cells at the site of inflammation. The receptor for OX40L is OX40 (CD134) which is expressed predominantly on activated CD4+T cells. Expression of OX40 is ...
proliferation, prolongs the immune response, and enhances the number of cells making the transition from effector to memory T cells (1‑6). OX40 signal transduction includes binding TNF receptor-associated factors (TRAFs), and activating NF kappa B and PI3 kinase to enhance expression of ...
The interest on OX40R-OX40L system is related to the fact that, even if the intracellular signaling mechanisms have not yet completely understood, the expression profile of OX40R makes this protein a peculiar target for CD4+T cells mediated diseases in clinical settings, for example in multipl...