Fig2. Anti-OX40 mechanism of action based on in vitro versus in vivo rationale. In vitro experiments show that anti-OX40 will enhance CD4 and CD8 survival. Anti-OX40 has diverging effects on Tregs cell (increased and decreased survival, inhibition of FoxP3 expression). In vivo experiments w...
29.Petty,J.K.,He,K.,Corless,C.L.,Vetto,J.T.,and Weinberg,A.D.(2002) .Survival in human colorectal cancer correlates with expression of the T‑cell costimulatory molecule OX‑40(CD134).American journal of surgery 183,512‑518. 30.Redmond,W.L.,and Weinberg,A.D.(2007)....
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for product...
Fig 1. Expression of OX40 in the spleen lymphocytes of humanized OX40 mice is detected by FACS. The spleen lymphocytes of heterozygous humanized OX40 mice were activated by anti-CD3 and anti-CD28 for 48 hours, and then collected for staining. Along with a group undergoing no stimulation, th...
in vivo OX40 activation Kurche, J. S., et al. (2012). “Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression.” J Immunol 188(2): 585-593 ...
iantumorcells,isapotentproangiogeniccytokine[J].Cancer Res,2005,65(23):10794-10800. [8]WilliamS,MarkS,JasbirS.1.9Acrystalstructureofinterleukin 6:implicationsforanovelmodeofreceptordimerizationandsig- naling[J].EMBOJ,1997,16(5):989-997.
in situ hybridization. CD134 is the primary receptor for feline immunodeficiency virus. CD134 expression can promote viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Stimulating the receptor can improve the response to a powerful virus vector ...
The exceptional immunostimulatory capacity of DCs makes them potential targets for investigation of cancer immunotherapeutics. We show here in mice that TNF-alpha-stimulated DC maturation was accompanied by increased expression of OX40 ligand (OX40L), the lack of which resulted in an inability of ...
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flowcytometric analysis and the oligomer sequence is confirmed by sequencing. TotalSeq™-Aantibodies are compatible with 10x Genomics Single Cell Gene Expression Solutions. ...
Ramser et al., “High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy,” BMC Cancer, 2018, pp. 1-9, vol. 18, article No. 425. Yokouchi et al., “Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic a...