Fine-needle aspiration (FNA) or percutaneous biopsy of an adnexal mass is not routinely recommended, as it may delay diagnosis and treatment of ovarian cancer. Instead, if a clinical suggestion of ovarian cancer is present, the patient should undergo laparoscopic evaluation or laparotomy, based on ...
Ovarian cancer represents one of the cancers with the worst prognostic in adult women. More than half of the patients who present with clinical signs such as abdominal bloating and a feeling of fullness already show advanced stages. The majority of ovarian cancers grow as cystic masses, and canc...
MSLN is identified as a critical player in regulating ovarian cancer pathophysiology through IL-6/STAT3 signaling19 while correlating with immune infiltration and chemoresistance as a prognostic biomarker in ovarian cancer40. Moreover, MSLN’s impact on the ovarian cancer microenvironment was known to ...
We found the EV proteomes of cell lines may reflect the pathophysiology of early-stage HGSC, such as inflammation [36], ECM remodeling [37] and angiogenesis [38]. However, many similarities were noted between cancer cells and the non-malignant hIOSE, pointing to potential confounders associated...
Personalized medicine remains an unmet need in ovarian cancer due to its heterogeneous nature and complex immune microenvironments, which has gained increasing attention in the era of immunotherapy. A key obstacle is the lack of reliable biomarkers to id
To gain further insight for the possible involvement of these genes in ovarian cancer pathophysiology, we examined whether expression levels of these genes are clinically relevant by using the comprehensive data from The Cancer Genome Atlas. Interestingly, these gene expression data suggested that COL...
Hsa-miR-141-3p (miR-141), an exosomal miRNA, is highly secreted by ovarian cancer cells and reprograms stromal fibroblasts into proinflammatory cancer-associated fibroblasts (CAFs), facilitating metastatic colonization. A mechanistic study showed that miR-141 targeted YAP1, a critical effector of the...
Despite these clinical associations, the precise pathophysiology of how overnutrition affects female reproduction remains elusive. In this study, we established a mouse model with obesity and hyperglycemia induced by a high-fat and high-sucrose diet, which mimics the modern lifestyle of overnutrition,...
F. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 64(15), 5245–5250. https://doi.org/10.1158/0008-5472.CAN-04-0496 (2004...
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer. 2021;27(5):820–32. https://doi.org/10.1038/s41591-021-01323-8. Zhou W, Gao F. Single-cell deletion analyses show control of pro-T cell developmental speed and pathways by Tcf7, Spi1,...