OT-II Mice 一、品系名称 品系名称:OT-II Mice 品系背景:C57BL/6J 毛色:黑色 相关基因型:a/a 二、品系描述 T细胞是一种在免疫反应中起着关键作用的白细胞,主要有CD4+T细胞(辅助性T细胞)和CD8+T细胞(杀伤性T…
OT-II和OT-I小鼠都是T细胞受体（TCR）转基因鼠。OT-II小鼠的CD4 T细胞可以识别OVA抗原（OVA-323-339），而OT-I小鼠的CD8 T细胞可以识别OVA抗原（OVA-257-264）。这些小鼠常被用作研究免疫反应和疫苗的模型。
回答者:网友 OT-II:(CD4+---ovalbumin 323-339 ) These transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b.Homozygous mice are viable and fertile.In these mice...
CD86 seems to be the main costimulatory molecule involved in the proliferation response but CD80 is the main costimulatory molecule influencing cytokine secretion in pregnant mice. In conclusion, this study showed that CD80 and CD86 costimulatory molecules regulate OT-II CD4+ T lymphocyte proliferation ...
2、大鼠模型对抗藤反应较为一致,能出现与人类哮喘类似的迟发相反应,并有嗜酸的粒细胞浸润和气道反应性...
OVA specific OT-II CD4+Tcells showed reduced cytokine production and lung infiltration in OVA immunized mice.M. Akirav, EitanHenegariu, OctavianPrestonHurlburt, PaulaMarie Schmidt, AnnClynes, RaphaelC. Herold, Kevan
OVA specific OT-II CD4+Tcells showed reduced cytokine production and lung infiltration in OVA immunized mice. E M. Akirav,O Henegariu,P Prestonhurlburt,... 被引量: 0发表: 2014年 Estrogen receptor alpha (ERalpha) deficiency in macrophages results in increased stimulation of CD4+ T cells ...
通用名称:OT-II 这些OT-II转基因小鼠表达小鼠α链和β链T细胞受体,该受体与CD4共受体配对,在I-Ab(CD4共受体与组织相容性复合体(major histocompatibility complex, MHC)II类分子相互作用)背景下,特异性结合鸡卵清蛋白323-339肽段。这导致CD4+ T细胞主要识别由MHC II类分子呈递的卵清蛋白肽段323-339。在这些小鼠...
2000). In the brain, both in mice and humans, the long isoforms of otoferlin are predicted to lack part of the first inter C2 domain and to contain a TM domain encoded by exon 47. The murine transcripts may or may not contain a region of the fourth inter C2 domain encoded by the 5...
frequency of MHC class I-restricted, ovalbumin-specific, CD8+ Tcells(OT-I cells). These mice ...