Osteolytic metastasesOsteoblastic metastasesOsteoclastsOsteoblastsVicious cyclePre-metastatic nicheTGFβPTHrPRANKLSome of the most common cancer types have a propensity to metastasize to bone. When cancer metastasizes to bone, it causes osteolysis and abnormal new bone formation. The phenotypes of ...
1 Conversely, the clinical co-targeting of osteoclasts, responsible for a fraction of osteolytic metastases, has indicated that osteoclasts only had a secondary role in prostate cancer progression. Clinical trials with agents such as zolenodrate or denosumab, which inhibit osteoclast activity, showed ...
As such, this study aimed to develop a low complexity semiautomated multimodal μCT/μMR based approach to segment rat vertebral structure affected by mixed osteolytic/osteoblastic destruction. METHODS: Mixed vertebral metastases were developed via intracardiac injection of Ace-1 canine prostate cancer...
81 - MP-08.14: Eradication of osteoblastic and osteolytic skeletal metastases of hormone refractory prostate cancer (mHRPC) after treatment with pegylated trispecific disulfide linked Fv (sdFv) targeting epitopes of EGFR, PTHrP and RANKL conjugated covalently with SATA to vinorelbine tartrate - EM|...
Differences of osteoblastic bone metastases and osteolytic bone metastases in clinical features and molecular characteristics. Clin Transl Oncol 2015; 17(3):173-9.Fang J, Xu Q. Differences of osteoblastic bone metastases and osteolytic bone metastases in clinical features and molecular characteristics....
Metastases are classified into three types: osteolytic, mixed, osteoblastic. However, the patient population with spinal metastases that is most likely to benefit from PVP is uncertain. The purpose of this study was to determine the analgesic efficacy of vertebroplasty for osteolytic or osteoblastic ...
Basic mechanisms responsible for osteolytic and osteoblastic bone metastases. Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6213s-6s.Guise TA, Mohammad KS, Clines G, et al. Basic mechanisms responsible for osteolytic and osteoblastic bone metastases. Clin Cancer Res 2006; 12(20 Pt 2): 6213s...
(2009) A single pretreatment by zoledronic acid converts metastases from osteolytic to osteoblastic in the rat. Microscopy Research and Technique , NA-NA /Nyangoga H, Blouin S, Libouban H, Basle´ MF, Chappard D. A single pretreatment by zoledronic acid converts metastases from osteolytic...
Minimal osteolytic changes: the initial manifestations of bone metastases and the primary stage of osteoblastic metastases.YanQing ChenYang YangYanFen XingSen JiangXiWen Sun
Lipton A,Small E,Saad E,et al.The new bisphosphonate, Zometa ( zoledronic acid) , decreases skeletal complications in both osteolytic and osteoblastic lesions: a comparison to pamidronate.Cancer Investigation. 2002Lipton A, Small E, Saad F, Gleason D, Gordon D, Smith M, Rosen L, Kowalski ...