甘景卓 【摘要】目的 研究原发性肝细胞癌（ＨＣＣ）中ＬｎｃＲＮＡＯＳＥＲ１ ＡＳ１与ｍｉＲ ６１２表达的相关性及生物学意义。方法 收集２０１７年３月 ２０２０年３月华北理工大学附属医院手术切除并保存的ＨＣＣ组织及对应的癌旁组织，培养ＨＣＣ细胞株ＳＭＭＣ ７７２１、ＨｅｐＧ２、ＢＥＬ ...
OSER1-AS1靶向miR-433-3p.结果HCC组织中LncRNA OSER1-AS1的表达水平高于癌旁组织(1.77±0.34 vs1.00±0.21),miR-433-3p的表达水平低于癌旁组织(0.65±0.09 vs 1.00±0.28)(P<0.05)且LncRNA OSER1-AS1与miR-433-3p呈负相关(r=-0.351,P<0.05);HCC细胞株中LncRNA OSER1-AS1的表达水平高于HL-7702细胞...
迁移数及Ki-67,基质金属蛋白酶-2,基质金属蛋白酶-9蛋白表达.OSER1-AS1靶向结合并负调控miR-373-3p;下调miR-373-3p可干扰OSER1-AS1对AngⅡ诱导HASMCs增殖,迁移的影响.结论OSER1-AS1在AS患者血清,AngⅡ诱导的HASMCs中表达上调,miR-373-3p表达下调;OSER1-AS1可能通过靶向下调miR-373-3p促进AngⅡ诱导HASMCs...
长链非编码RNA OSER1-AS1 对缺氧环境下胃癌细胞上皮间质转化的机制 研究doi:10.3969/j.issn.1000-484X.2023.08.010喻卉关李稳刘真义Chinese Journal of Immunology
目的探讨LncRNA OSER1-AS1/miR-149-5p对口腔鳞癌细胞HSC-3增殖,迁移,侵袭,凋亡的影响及其可能作用机制.方法采用qRT-PCR法检测口腔鳞癌组织与癌旁组织中OSER1-AS1,miR-149-5p的表达量;si-NC,si-OSER1-AS1,si-OSER1-AS1与NC,si-OSER1-AS1与miR-149-5p inhibitor分别转染入HSC-3细胞;采用qRT-PCR法检测...
Here, we investigated the role of OSER1-AS1 in the progression of HCC. The results of database and qRT-PCR analysis demonstrated that OSER1-AS1 was highly expressed in HCC tissues and the high expression of OSER1-AS1 was closely associated with larger tumor size, advanced tumor stages, ...
OSER1 antisense RNA 1 (OSER1-AS1), a long noncoding RNA, has been well studied in the context of hepatocellular carcinoma. However, its expression status, specific functions, and tumorigenic mechanism in non-small cell lung cancer (NSCLC) remain uninvestigated. Hence, this study aimed to ...
OSER1-AS1的表达水平高于正常肝细胞株HL-7702,miR-612的表达水平低于正常肝细胞株HL-7702(P<0.05),其中HepG2细胞中LncRNA OSER1-AS1,miR-612表达的变化最显著.转染siRNA敲低LncRNA OSER1-AS1后,细胞存活率及FOXM1表达水平降低,凋亡率及miR-612表达水平增加;转染miR-612模拟物后,LncRNA OSER1-AS1双荧光...