图片来源:Park SE, Georgescu A, Huh D. Organoids-on-a-chip. Science. 2019 Jun 7;364(6444):960-965. doi: 10.1126/science.aaw7894 . 图片来源:Wang Y, Wang L, Zhu Y, Qin J. Human brainorganoid-on-a-chip to model prenatal nicotine exposure. Lab Chip. 2018 Mar 13;18(6):851-860....
Organoids-on-a-chip is a newly emerging and frontier field with a marriage of organoids and microfluidic organ-on-a-chip technology. The synergistic engineering strategies can be adopted to build organ model systems in high fidelity, and to hold great potential in studies of organ development,...
Organoids-on-a-chip 来自 science.org 喜欢 0 阅读量: 496 作者:SE Park,A Georgescu,D Huh 摘要: Recent studies have demonstrated an array of stem cell-derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo ...
Organoids-on-chips is a next-generation high-throughput, high-bionic in vitro model construction platform created by combining the two cutting-edge technologies in the life science and engineering fields of "organoid" and "organ chip", which has a wide range of applications in new drug research...
responses based on these two models and the feasibility of adjusting treatment strategies in clinical patients based on this predictive effect as a supplement to the clinical treatment reference index. Finally, we discuss the two models’ limitations and look forward to organoids-on-a-chip ...
In the current review, we will provide an overview of recent advances ininvitromodeling for personalized drug testing based on stem cell and organ-on-a-chip technologiesand illustrate how these developments will eventually lead to the replacement of animal testing. Particular focus will be on ...
Reconstituting organ-level lung functions on a chip. Science 328, 1662–1668 (2010). This article was the first to define the ‘organ-on-a-chip’ term, describing a microfluidic device that recapitulated endothelial–epithelial interface for studies of barrier function. Google Scholar Viravaidya,...
Reconstituting organ-level lung functions on a chip. Science 328, 1662–1668 (2010). This article was the first to define the ‘organ-on-a-chip’ term, describing a microfluidic device that recapitulated endothelial–epithelial interface for studies of barrier function. Google Scholar Viravaidya,...
Journal of Nanobiotechnology (2022) 20:308 https://doi.org/10.1186/s12951-022-01518-2 Journal of Nanobiotechnology REVIEW Open Access Pancreatic islet organoids‑on‑a‑chip: how far have we gone? Jiaxiang Yin1,2,3, Hao Meng2, Jingfang Lin1, Wei Ji1,3, Tao Xu2,4*...
Diabetes mellitus (DM) is a disease caused by dysfunction or disruption of pancreatic islets. The advent and development of microfluidic organoids-on-a-chip platforms have facilitated reproduce of complex and dynamic environment for tissue or organ devel