Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more physiologically relevant system in vitro. Common designs for VOoC primarily involve two categories: self-assembly of endothelial cells (ECs) to form microvessels and pre-patterned...
Organoids-on-a-chip is a newly emerging and frontier field with a marriage of organoids and microfluidic organ-on-a-chip technology. The synergistic engineering strategies can be adopted to build organ model systems in high fidelity, and to hold great potential in studies of organ development,...
Organoid and Organ-on-a-chip Imaging Products Related Literature Discussion Related Solutions Glossary ContactMicroscope Products Confocal and Multiphoton Microscopes Super-Resolution Microscopes Inverted Microscopes Upright Microscopes Polarizing Microscopes Stereo Microscopes Software Photostimulation & TIRF Light So...
Finally, we define implementation limitations and requirements for translation of the integrated devices, including determining the differentiation stage at which an organoid should be placed into an organ-on-a-chip device, providing perfusable vasculature within the organoid and overcoming limitations of ...
Heart disease has confounded the medical profession largely because the heart is so intolerant of even momentary lapses in function. To meet this challenge, researchers need tools that are just as agile as the problem. Using an electrically sensitive organoid o...
Gastrointestinal organs and organoids-on-a-chip: advances and translation into the clinics, Mariana R Carvalho, Le-Ping Yan, Bo Li, Chang-Hua Zhang, Yu-Lon... MR Carvalho,LP Yan,B Li,... 被引量: 0发表: 2023年 Microfluidic organoids-on-a-chip: The future of human models 2022 Elsevi...
Lissencephalic (smooth brain) organoids display reduced convolutions, modified scaling and a reduced elastic modulus. Although the mechanism here does not include the neuronal migration seen in vivo, it models the physics of the folding brain remarkably well. Our on-chip approach offers a means ...
In recent years, advances in tissue engineering and microfabrication technologies have enabled rapid growth in the areas of in vitro organoid development as well as organoid-on-a-chip platforms. These 3D model systems often are able to mimic human physiology more accurately than traditional 2D cultur...
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