The 3D organization of chromatin modulates biological processes such as transcription, DNA replication, cell division and meiosis, which are crucial for cell differentiation and animal development. In this Review, we discuss recent progress in our understanding of the general principles of chromatin ...
The locations of the cell bodies of origin of a pathway ascending in the dorsal part of the lateral funiculus of the cat spinal cord were mapped. It is presumed that the pathway is the spino-cervical tract. The locations of the neurons were determined by recording the antidromic action poten...
{N}}}\). Here,\({x}_{i}\)represents the expression features of the cell or spot\(i\), while the element\({{{\bf{A}}}_{i,j}\)in adjacency matrix is equal to 1 if there is an edge between cell/spot i and j, otherwise,\({{{\bf{A}}}_{i,j}=0\). We provide two ...
Cellares is the first Integrated Development and Manufacturing Organization (IDMO) and takes an Industry 4.0 approach to mass manufacturing the living drugs of the 21st century. The company is both developing and operating integrated technologies for cel
4. Single-cell RNA-seq of human fibroblasts 最后作者在人的组织上验证了前面的结果 Extended Data Fig. 9A-C:作者对3例胰腺癌患者的癌和癌旁组织进行了单细胞测序,得到21262个细胞,鉴定出了C3和C8这两群成纤维细胞。C3是肿瘤相关成纤维细胞(CAF),C8则是正常成纤维。
Contractility Driven Self-Organization of the Actin Cytoskeleton Tee YH, Shemesh T, Thiagarajan V, Hariadi RF, Anderson KL, Page C, Volkmann N, Hanein D, Sivaramakrishnan S, Kozlov MM, Bershadsky AD: Cellular chirality arising from the self- organization of the actin cytoskeleton. Nat Cell ....
INVESTIGATION of the cytology and ultrastructure of fifteen species drawn from twelve genera of coccoid Xanthophyceae (carried out in conjunction with a similar study of nineteen species drawn from four filamentous genera 1,2 ) reveals that this algal class contains two structural series. The morp...
The cell nucleus stores the genetic material essential for life, and provides the environment for transcription, maintenance, and replication of the genome
Membrane rafts potentially have crucial physiological roles across cell types that range from immune cells to cancer cells. Membrane domains are conserved throughout the domains of life, which supports their functional importance in biological systems. Abstract Cellular plasma membranes are laterally heterog...
Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. Their potential heterogeneity at different ages and midline locations is va