ArticleThe protein organization of a red blood cell Author links open overlay panelWisath Sae-Lee 1, Caitlyn L. McCafferty 1, Eric J. Verbeke 1, Pierre C. Havugimana 2, Ophelia Papoulas 1, Claire D. McWhite 1, John R. Houser 1, Kim Vanuytsel 3, George J. Murphy 3, Kevin Drew ...
Cell Biol. 62:1-19.Steck, T. L. The Organization of Proteins in the Human Red Blood Cell Membrane: A Review. J. Cell. Biol. 1974, 62, 1-19.Steck T.L., The Organization of Proteins in the Human Red Blood Cell Membrane: A Review. J. Cell Biol. 62(1), 1-19, (1974)....
While there is detailed knowledge of the composition of RBC membranes, information about the molecu- lar organization of these components in the actual membranes is scarce6. This is, in particular, a consequence of the lack of suitable experimental techniques. The disordered, patchy and highly ...
The intact FnIII-2 domain in the IGF1R precursor also contains a long insertion domain (ID) connecting the α- and β- chains generated by proteolytic cleavage at a site within ID1. Extensive structural studies of the IGF1R protein family have revealed a novel mechanism of receptor auto...
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking. Here, we perform single-cell RNA sequencing on freshly ...
Transcriptome sequencing showed that adenosine-to-inosine (A-to-I) RNA editing was responsible for 80% of the editing events in the myocardium. Failing human hearts were characterized by reduced RNA editing. This was primarily attributable to Alu elements in introns of protein-coding genes. In ...
Moreover, the effect of dietary and blood glucose control on the stroma have been barely characterized, although blunt reduction in caloric intake, without malnutrition, showed promising anti-tumorigenic effects [33]. Nevertheless, how dysmetabolism affects PDAC stroma organization deserves dedicated ...
生理学英文(细胞)Basic-Function-of-the-Cell.pdf,Chapter 2. Basic Function of the Cell 12/2/2020 ◼ There are about 100 trillion (万亿) cells in a human being ( red blood cells about 25 trillion). ◼ Each of 100 trillion is a living structure that can
Crescent-shaped red blood cells, the hallmark of sickle-cell disease, present a striking departure from the biconcave disc shape normally found in mammals. Characterized by increased mechanical fragility, sickled cells promote haemolytic anaemia and vaso
Gene expression involves transcription, translation and the turnover of mRNAs and proteins. The degree to which protein abundances scale with mRNA levels and the implications in cases where this dependency breaks down remain an intensely debated topic. H