2020. https://www.fda.gov/drugs/development-approval-process-drugs/drug-approvals-and-databases Date AA, Hanes J, Ensign LM. Nanoparticles for oral delivery: Design, evaluation and state-of-the-art. J Control Release. Elsevier B.V.; 2016;240:504–26. Holmgren J, Czerkinsky C. Mucosal ...
Ethical Approval “This article does not contain any studies with human participants performed by any of the authors.”“This article does not contain any studies with animals performed by any of the authors.”“This article does not contain any studies with human participants or animals performed...
Paclitaxel-loaded TPGS- b -pcl nanoparticles: in vitro cytotoxicity and cellular uptake in MCF-7 and MDA-MB-231 cells versus mPEG- b -pcl nanoparticles and abraxane ® J. Nanosci. Nanotechnol., 16 (2016), pp. 160-170, 10.1166/jnn.2016.10739 View in ScopusGoogle Scholar ...
KEYTRUDA, in combination with carboplatin and either paclitaxel or paclitaxel protein-bound, is indicated for the first-line treatment of patients with metastatic squamous NSCLC. KEYTRUDA, as a single agent, ...
Carr-Locke injection needle Microneedle injection (Endoscopic) This device is composed of a polymeric external catheter that is wrapped around a metallic needle The whole GI tract 2.5 mm × 2300 mm (Endoscopic device) Vasoactive agents, sclerotherapy drugs, botulinum toxin, paclitaxel 37, ...
dendritic cell (DC) maturation and precise regulation of T cells. Furthermore, studies reported that the engineering ofSalmonella Typhimuriumbacteria with biotin molecules displayed on their outer membrane proteins were designed to bind to streptavidin-coated liposomes loaded with paclitaxel, resulting in ...
Oral squamous cell carcinoma (OSCC) treatment represents a great challenge, since platinum-based therapeutic agents have deleterious effects on normal cells and tissues. Employing gold nanoparticles (AuNps) as carriers for cisplatin have proved effective
(see Navarro et al., ESMO 2018 poster). Iadademstat is being evaluated in a collaborative Phase II basket study with the Fox Chase Cancer Center in combination with paclitaxel in R/R neuroendocrine carcinomas, and the company is preparing a new trial in combination in SCLC....
Oral squamous cell carcinoma (OSCC), a type of oral cancer, has a high mortality rate and unfavorable outcomes. Its tumor microenvironment (TME) is intricate and adaptable, with research frequently focusing on the immune reaction. Scholars are exploring ways to enhance survival by bolstering the ...
When the therapeutic was administered via PLGA nanoparticles modified with carnitine, higher drug bioavailability was observed; this was also because particle internalization reduced the effect of P-gp, which strongly inhibits paclitaxel. Optimized Na+ concentration further improved the process, while ...