Use of atazanavir without ritonavir is not recommended when coadministered with drugs that are highly dependent on CYP2C8 metabolism and have narrow therapeutic indices (e.g., paclitaxel, repaglinide). When ritonavir-boosted atazanavir is coadministered with substrates of CYP2C8, clinically significan...
Efficacy of certain antineoplastic agents (e.g., irinotecan, paclitaxel, teniposide) may be impaired by phenytoin Monitor serum phenytoin concentrations and adjust dosage of phenytoin accordingly Dosage adjustment of some antineoplastic agents may be necessary when phenytoin is added to or withdrawn from...
However, due to the hypermethylation of the promoter, the critical protein Gasdermin E (GSDME) is lacking in the majority of cancer cells, which cannot start the pyroptosis process and leads to dissatisfactory therapeutic effects. Additionally, the quick clearance, systemic side effects, and low ...
Yinchenhao Decoction is also a well-known classic TCM prescription for the treatment of acute icteric hepatitis, cholecystitis, and cholelithiasis, etc. In general, Yinchenhao Decoction consists of several herbal medicines, including Herba Artemisiae Scopariae, Fructus Gardeniae, Radix et Rhizoma Rhei,...
Do not use the reconstituted solution if it is cloudy or discolored. Use immediately to prepare a diluted TRODELVY infusion solution. Dilution Calculate the required amount of the reconstituted TRODELVY solution needed to obtain the appropriate dose according to the patient’s body weight. ...
Do not use the reconstituted solution if it is cloudy or discolored. Use immediately to prepare a diluted TRODELVY infusion solution. Dilution Calculate the required amount of the reconstituted TRODELVY solution needed to obtain the appropriate dose according to the patient’s body weight. ...
and paclitaxel [283]. The application of advanced technologies in the purification and screening of bioactive compounds from TCM has transformed the drug discovery landscape. These advanced technological tools, encompassing a spectrum of methodologies such as high-resolution mass spectrometry, high-resolutio...
Carboplatin + paclitaxel 145 12.3 51.0 -8.2% (95% CI -19.6% to 3.3%) 25.5 4.5 (P = 0.355)a 3.2 (P = 0.282)a 32.4 (P = 0.801)b 4.0 (n = 47) Cisplatin + gemcitabine 146 14.0 59.6 0.4% (95% CI -10.9% to11.7%) 31.5 4.0 (P = 0.170)a 3.2 (P = 0.567)a 30.1 (P = 0....
Paclitaxel In vitro evidence that ketoconazole can inhibit metabolism of paclitaxel Clinical importance unclear; use concomitantly with caution; monitor for increased or prolonged paclitaxel effects and reduce paclitaxel dosage if needed Phosphodiesterase type 5 (PDE5) inhibitors (sildenafil, tadalafil, vard...
Antineoplastic agents (e.g., bortezomib, cisplatin, docetaxel, paclitaxel, vincristine) Increased risk of neuropathy Use concomitantly with caution β-Adrenergic blocking agents Increased risk of bradycardia Calcium channel blocking agents Increased risk of bradycardia CNS depressants (e.g., alcohol...