发生于密码子 L718 和 G719(ATP 结合位点)和 G724(P-loop结构域)的其他突变也影响了奥希替尼的耐药,但这两种突变对第一/二代EGFR 抑制剂敏感。 “off-target”耐药性:EGFR通路非依赖性耐药机制 在接受奥希替尼治疗的7%~15% 患者中观察到MET扩增,获得性HER2扩增占比仅2%~5%。针对MET扩增,临床上已有可用药...
On-target and off-target effects of novel orthosteric and allosteric activators of GPR84Many members of the G protein-coupled receptor family, including examples with clear therapeutic potential, remain poorly characterised. This often reflects limited availability of suitable tool ligands with which to...
A major challenge in the application of the CRISPR-Cas13d system is to accurately predict its guide-dependent on-target and off-target effect. Here, we perform CRISPR-Cas13d proliferation screens and design a deep learning model, named DeepCas13, to pred
On-target refers to exaggerated and adverse pharmacologic effects at the target of interest in the test system. Off-target refers to adverse effects as a result of modulation of other targets; these may be related biologically or totally unrelated to the target of interest. Both the risk ...
on-target off-tumor effect的意思 "On-target off-tumor effect"是一个生物学术语,通常用于描述在肿瘤靶向治疗过程中出现的副作用。 以car-t治疗为例,希望靶抗原只在肿瘤细胞上表达,这样就不会对正常组织细胞造成影响。然而,一些主要在肿瘤细胞上表达的抗原,其实在某些正常细胞也存在少量表达,因此car-t靶向治疗时...
1.Karen A. Autio et al,Probody Therapeutics: An Emerging Class of Therapies Designed to Enhance On-Target Effects with Reduced Off-Tumor Toxicity for Use in Immuno-Oncology,Clin Cancer Res 2020;26:984–9 2.Polu KR, Lowman ...
正确顺序应该是on target-off tumor。一种药物或者其他小分子可以特异性结合肿瘤抗原，被用来治疗肿瘤。但是它可以与肿瘤抗原与结合以外，还可以与正常组织上的某种抗原结合。这种正常组织上的抗原可以与这种药物靶向结合，即为on target，但是又不在肿瘤上，即off tumor。药物靶向识别正常组织上的抗原，会...
1.Karen A. Autio et al,Probody Therapeutics: An Emerging Class of Therapies Designed to Enhance On-Target Effects with Reduced Off-Tumor Toxicity for Use in Immuno-Oncology,Clin Cancer Res 2020;26:984–9 2.Polu KR, Lowman HB. Probody therapeutics for targeting antibodies to diseased tissue....
本篇文章我们介绍一下罗氏旗下Genentech利用三特异抗体解决靶向激活T细胞的On-target off tumor效应,其主要是通过抗体同时靶向肿瘤细胞表明不同的靶点,促进抗体对肿瘤细胞的定位,并特异性杀伤肿瘤。 1 同时靶向Ly6E和B7-H4 同时靶向肿瘤细胞表面两个不...
We proposed a mathematical model to describe the "on-target" and "off-tumor" effects of CAR-T cell therapy on gliomas, and we investigated which parameters influenced the final outcome using a global sensitivity analysis. Our model highlights the dynamics of CAR-T cell therapy, tumor, and ...