on-target off-tumor effect的意思 "On-target off-tumor effect"是一个生物学术语,通常用于描述在肿瘤靶向治疗过程中出现的副作用。 以car-t治疗为例,希望靶抗原只在肿瘤细胞上表达,这样就不会对正常组织细胞造成影响。然而,一些主要在肿瘤细胞上表达的抗原,其实在某些正常细胞也存在少量表达,因此car-t靶向治疗时...
Effect of two different doses of esmolol on target effect-site concentration of propofol given by TCI during maintenance of anesthesia in laparoscopic operations艾司洛尔异丙酚靶控输注脑电双频指数目的 探讨腹腔镜手术患者麻醉中持续静脉输注艾司洛尔对靶控输注异丙酚效应室浓度的影响.方法 择期...
of the agents that have been classified as ‘non-lysosomotropic’ still might act on lysosomes, as this is the case for bafilomycin A1, which acts as an inhibitor of the vacuolar-type H+-ATPase (V-ATPase) enzyme and therefore abolishes lysosomal acidification through an on-target effect. Henc...
A major challenge in the application of the CRISPR-Cas13d system is to accurately predict its guide-dependent on-target and off-target effect. Here, we perform CRISPR-Cas13d proliferation screens and design a deep learning model, named DeepCas13, to pred
Furthermore, implications about the effect of target facial sexual dimorphism on participants' trustworthiness perception were discussed. 展开 关键词: facial attractiveness feminine masculine sexual dimorphism trustworthiness DOI: 10.3389/fpsyg.2018.00942 年份: 2018 ...
The effect of target postgrazing height on sward clover content, herbage yield, and dairy production from grass-white clover pasture. J. Dairy Sci. 96:1598-1611.Phelan, P., Casey, I. a, & Humphreys, J. (2013). The effect of target postgrazing height on sward clover content, herbage...
There was no detrimental effect of Vip cotton on egg parasitoids. The number of predatory beetles and the pest mirid Creotiades dilutus (Stål) was higher in the Vip, although the increase in mirids was probably the result of more food (bolls) in the Vip crop. In a small plot ...
The effect of target-background synchronicity on speech-in-speech recognitionThe aim of the present study was to investigate whether speech-in-speech recognition is affected by variation in the target-background timing relationship. Specifically, we examined whether within trial synchronous or ...
(2012). The effect of target language and code-switching on the grammatical performance and perceptions of elementary-level college French students. Foreign Language Annals, 45(1), 72-91.Viakinnou-Brinson, L., Herron, C., Cole, S. P., & Haight, C. (2012). The effect of target ...
and increased the ratio of on-target vs. off-target reads compared to the WT protein. However, in case of B-SpCas9, where these capping interactions are already interrupted, the fidelity-increasing effect of the 5′ G-extension is reduced (Fig.3band Supplementary Fig.5, Supplementary Data3...