on-target off-tumor effect的意思 "On-target off-tumor effect"是一个生物学术语,通常用于描述在肿瘤靶向治疗过程中出现的副作用。 以car-t治疗为例,希望靶抗原只在肿瘤细胞上表达,这样就不会对正常组织细胞造成影响。然而,一些主要在肿瘤细胞上表达的抗原,其实在某些正常细胞也存在少量表达,因此car-t靶向治疗时...
A major challenge in the application of the CRISPR-Cas13d system is to accurately predict its guide-dependent on-target and off-target effect. Here, we perform CRISPR-Cas13d proliferation screens and design a deep learning model, named DeepCas13, to pred
of the agents that have been classified as ‘non-lysosomotropic’ still might act on lysosomes, as this is the case for bafilomycin A1, which acts as an inhibitor of the vacuolar-type H+-ATPase (V-ATPase) enzyme and therefore abolishes lysosomal acidification through an on-target effect. Henc...
There was no detrimental effect of Vip cotton on egg parasitoids. The number of predatory beetles and the pest mirid Creotiades dilutus (Stål) was higher in the Vip, although the increase in mirids was probably the result of more food (bolls) in the Vip crop. In a small plot ...
Furthermore, implications about the effect of target facial sexual dimorphism on participants' trustworthiness perception were discussed. 展开 关键词: facial attractiveness feminine masculine sexual dimorphism trustworthiness DOI: 10.3389/fpsyg.2018.00942 年份: 2018 ...
we demonstrated that low-affinity/high-avidity fine-tuned G9 CAR-T has a wider therapeutic window compared to high-affinity/high-avidity G250 that was used in the first anti-CAIX CAR-T clinical trial but displayed serious OTOT effects. To assess the therapeutic effect of G9 on patient samp...
In point-and-click interfaces the location of targets is sometimes known to the user before visually identifying it, and sometimes not. This experiment investigates how pointing is affected by whether the target location is precued so that users know it in advance or nonprecued so that users...
The longitudinal and transverse momentum (PL and PYenT) distributions of projectile-like fragments, which were produced with an Ar beam and various targets (C, Al, Nb, Tb, Au),were measured at E=290A鈥塎eV. No significant target effects are found in P L distribution. The width of PT ...
Effect of the oxygen deficiency of ceramic TiO2x targets on the deposition of TiO2 thin films by DC magnetron sputtering "Effect of the oxygen deficiency of ceramic TiO2-x targets on the deposition of TiO2 thin films by DC magnetron sputtering," Surface and Interface Analysi... H Poelman,H ...
off-target up-regulated, off-target down-regulated and non-significantly altered pathways respectively. Abbreviations: Ato: Atrovastatin; Flu: Fluvastatin; Ros: Rosuvastatin; Sim:Simvastatin. In silico validation and and whether the effect has been previously observed in the literature is also indicate...