逃避抗肿瘤免疫是肿瘤的一个标志,因而各类肿瘤免疫疗法被开发,如免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)和T细胞再定向双特异性抗体(T-cell–redirecting bispecifics,TCBS)等。虽然免疫治疗延长了各类肿瘤患者的生存时间,但全身免疫激活效应也发生在健康组织中,导致免疫相关不良事件(Immune-related adverse eve...
逃避抗肿瘤免疫是肿瘤的一个标志,因而各类肿瘤免疫疗法被开发,如免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)和T细胞再定向双特异性抗体(T-cell–redirecting bispecifics,TCBS)等。虽然免疫治疗延长了各类肿瘤患者的生存时间,但全身免疫激活...
On-target refers to exaggerated and adverse pharmacologic effects at the target of interest in the test system. Off-target refers to adverse effects as a result of modulation of other targets; these may be related biologically or totally unrelated to the target of interest. Both the risk ...
susceptibility theory proposes that genetically determined appetitive traits, such as food responsiveness (FR) and satiety responsiveness (SR), interact with the environment and lead to overeating and weight gain; the regulation of cues (ROC) intervention was developed specifically to target FR and SR...
By pursuing the principle of stimulating domestic demand and adopting the proactive fiscal policy and the sound monetary policy in good time, we overcame the adverse effects the Asian financial crisis and world economic fluctuations had on China, and maintained a relatively rapid economic growth.【一...
Climate change, along with environmental pollution, can act synergistically on an organism to amplify adverse effects of exposure. The Arctic is undergoing profound climatic change and an increase in human activity, resulting in a heightened risk of
Because the trial was terminated early by the sponsor for enrollment below target, it was recognized that the study would be underpowered to formally test the hypothesis. Therefore, the statistical analysis plan was finalized, prior to database lock and unblinding, to evaluate the size of an ...
Examination of potential adverse effects on non-target organisms is an essential element in the environmental risk assessment of transgenic crops expressing Bacillus thuringiensis Cry toxin (Bt crops). Impacts of Bt crop pollens, in particular, have been a major concern due to the high potential of...
3. The main target of anti-VEGF agents: VEGF165 among pro-angiogenic and anti-angiogenic function—from one main actor to two opponents 4. Heterogeneous activities of the different VEGF isoforms: a hot topic to understand the effects of selective and non-selective VEGF inhibition 5. Developing ...
The advertisers seem to have a deep insight into consumers’ psychology and behavior which are taken advantage of in advertising to make their products whether a piece of clothes or a kind of snack more appealing to the target audience. As a consequence, consumers are very likely to fall prey...