Thus, greater understanding of the relationship between alteration in the immune system and development and progression of HF is urgently necessary: prior to designing therapeutic interventions that target pathological inflammatory processes in preventing harmful cardiac effects of immune modulatory therapy. ...
Moreover, the risk of cardiotoxicity persists even with the targeted therapy, the newer type of cancer treatment, due to the presence of on-target and off-target effects related to this new class of drugs. The potential cardiovascular toxicity of anticancer agents includes: QT prolongation, ...
Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways. Leukemia 24, 13–21 (2010). Article CAS Google Scholar Rosilio, C. et al. L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/...
Classical PUVA therapy seems to have too many side effects; topical application of psoralen is promising but still experimental. Topically and systemically ... M Carrozzo,S Gandolfo - 《Oral Diseases》 被引量: 311发表: 1999年 Topical application of methotrexate for inhibition of corneal angiogenesis...
As one of the cutting-edge cancer treatments, targeted drug therapy has the advantages of high efficiency, few side effects, and low drug resistance for patients1. However, there are several drawbacks to the existing targeted therapies, such as a few druggable targets2, ineffective coverage of ...
Advances in the potential therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) [167,168] have encouraged the use of tDCS as an alternative therapy in PD. Although systematic reviews have not reported the benefit of tDCS for PD motor rehabilitation [92,169,170], nevertheless pr...
This was confirmed by the ability of MAgEC cells to home, in vivo, into a B16F10 tumor site and to be a good cell carrier for tumor cell-based gene therapy. Indeed, EPCs appear to be a tool of choice for angiogenesis targeting in view of tumor therapy (Fig. 6). Due to their ...
Early treatment, “treat-to-target” strategies, and biological therapy in patients with severe disease have made clinical remission an achievable goal.2-4 However, structural joint damage develops in approximately 20% to 30% of patients fulfilling remission criteria,5 indicating that current remission...
(NCT04394416). Indeed, imatinib is the sole agent that, to our knowledge, inhibits the replication of CoVs through an on-target effect, namely the inhibition of ABL2, as this has been shown for MERS-CoV and SARS-CoV25,48. Imatinib has few side effects, as demonstrated by its use for...
Signal Transduction and Targeted Therapy volume 8, Article number: 375 (2023) Cite this article 44k Accesses 108 Citations 160 Altmetric Metrics details Abstract The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, ...