on-target off-tumor effect的意思 "On-target off-tumor effect"是一个生物学术语,通常用于描述在肿瘤靶向治疗过程中出现的副作用。 以car-t治疗为例,希望靶抗原只在肿瘤细胞上表达,这样就不会对正常组织细胞造成影响。然而,一些主要在肿瘤细胞上表达的抗原,其实在某些正常细胞也存在少量表达,因此car-t靶向治疗时...
We proposed a mathematical model to describe the "on-target" and "off-tumor" effects of CAR-T cell therapy on gliomas, and we investigated which parameters influenced the final outcome using a global sensitivity analysis. Our model highlights the dynamics of CAR-T c...
We proposed a mathematical model to describe the "on-target" and "off-tumor" effects of CAR-T cell therapy on gliomas, and we investigated which parameters influenced the final outcome using a global sensitivity analysis. Our model highlights the dynamics of CAR-T cell therapy, tumor, and ...
One of the major hurdles that has hindered the success of chimeric antigen receptor (CAR) T cell therapies against solid tumors is on-target off-tumor (OTOT) toxicity due to sharing of the same epitopes on normal tissues. To elevate the safety profile of CAR-T cells, an affinity/avidity f...
Chimeric antigen receptors (CARs) can effectively redirect cytotoxic T cells toward highly expressed surface antigens on tumor cells. The low expression of several tumor-associated antigens (TAAs) on normal tissues, however, hinders their safe targeting by CAR T cells due to on-target/off-tumor ...
此外没有观察到表达AXL的正常组织有严重不良事件(on-target, off-tumor toxicity)。4个PR的肉瘤患者,AXL表达均大于70%。 肺癌上有意思的结果是,共4名患者,2名AXL阴性患者无效,1名患者不能评估,1名患者AXL阳性,获得了70%肿瘤缩小的结果,这名患者是NSCLC的IV期患者,并且是使用PD-1后治疗失败的患者,这对应的...
The proteolytically activated, unmasked HER2-TCE demonstrated highly potent cytotoxicity against high HER2-expressing tumor cells, SKOV3 (∼650,000 HER2 receptors per cell; Fig. 2b) and BT-474 (∼975,000 HER2 receptors per cell; Fig. 2c), showing nearly complete target cell killing with ...
Chimeric antigen receptors (CARs) combine T cell activation with antibody-mediated tumor antigen specificity, bypassing the need for T cell receptor (TCR) ligation. A limitation of CAR technology is on-target off-tumor toxicity caused by target antigen expression on normal cells. Using GD2 as a ...
A major challenge in the application of the CRISPR-Cas13d system is to accurately predict its guide-dependent on-target and off-target effect. Here, we perform CRISPR-Cas13d proliferation screens and design a deep learning model, named DeepCas13, to pred
67 Instead, p38 MAPK dephosphorylation by TTCC gene silencing suggests that p38 MAPK activation by treatment with mibefradil is an off-target effect, owing to cytosolic Ca2+ elevation (Fig. 1). TTCCs and the AKT pathway: A third positive feedback mechanism favoring tumor progression and ...