The TAAs used as targets for PCa immunotherapy described above are not unique to tumor tissues but are also expressed to a small extent in normal tissues, resulting in CAR-T attack regardless of malignant or healthy tissues, which leads to damage to the body, thus causing on-target off-...
1062P EGFR-XPAT, a novel pro-drug T-cell engager (TCEs) engineered to address on-target, off-tumour toxicity and an orthogonal approach for cancer immunotherapy in EGFR, KRAS/BRAF cancersB. IrvingA. NazeerF. CattaruzzaZ. LangeC. Koski...
Similar to what has been observed with 1st-generation drugs, this can be off-target (mainly through the activation of the MAPK pathway [19]) or on-target [20]. In the latter, the emergence of TRK xDFG single or compound mutations, which hinder drug binding, is the only mechanism known...
Since U2OS cells lack constitutive activation of ALK, this effect is clearly off-target and may be explained by the simultaneous inhibition of several tyrosine kinases by high crizotinib doses. Nevertheless, these observations created the precedent that TKIs can induce ICD, though through off-target...
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR The success of the CRISPR/Cas9 genome editing technique depends on the choice of the guide RNA sequence, which is facilitated by various websites. Despite ......
Proton therapy can deliver superior dose distributions compared with photon-based radiotherapy, enabling radiation oncologists to precisely target a tumour while reducing the risk of damage to adjacent healthy tissue. Pencil-beam scanning (PBS), the most advanced type of proton therapy, increases t...
aexhibits tumour-suppressive functions in ccRCC. 在ccRCC陈列肿瘤抑压作用。 [translate] aConduct MRT of charge pumps. Continue the compressor runs and preparation. Re-start short circulation. Continue Spring hanger release. Continue pressure test on the HP section. Conduct MRT on turbine GT-0012 ...
Xu F, Wang J, Bai S et al (2009) Detection of intrafractional tumour position error in radiotherapy utilizing cone beam computed tomography. Radiother Oncol 89:311–319 Article Google Scholar Suzuki M, Nishimura Y, Nakamatsu K et al (2006) Analysis of interfractional set-up errors and intr...
LKB1 protein following the introduction of a frameshift-inducing INDEL: Super LKB1, ATI LKB1, and Short LKB1 (Supplementary Fig.7E). More generally, our observations also suggest that introducing INDELs early in the transcript increases the potential for an ATI event that is able to clear off ...
35. Chia SL, Yusoff K, Shafee N. Viral persistence in colorectal cancer cells infected by Newcastle disease virus. Virology journal. 2014;11:91 36. Feng XX, Wang Z, Shi JZ, Deng GH, Kong HH, Tao SY. et al. Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 ...