Fahn S. ‘On-off’ phenomenon with levodopa therapy in parkinsonism: clinical and pharmacologic correlations and the effect of intramuscular pyridoxime. Neurology 1974; 24: 431–41Fahn, S., The ‘on-off’ phenomenon with levodopa therapy in parkinsonism: clinical and pharmacologic correlations and...
Critical Review: Effect of Levodopa (L-dopa) medication on speech intelligibility and articulation in individuals with Idiopathic Parkinson's Disorder (IPD) repeated. Four speech-language pathologists evaluated the video-recorded tapes. Each recording was presented once and `off' and `on' samples were...
Irregularities in motor response after continuing levodopa therapy of Parkinson disease (the "on-off effect") were assessed with the addition of l-α-methydopa hydrazine (carbidopa) in a doubleblind study. Thirteen of 20 patients improved while receiving carbidopa and levodopa while only four of ...
The possible mechanism of the "off-on" phenomenon and some suggestions to influence it, are presented. 展开 关键词: Off-On” effect Parkinson disease Levodopa Decarboxylase inhibitor DOI: 10.1007/BF00312550 被引量: 13 年份: 1977
Such fluctuations may be unpredictable, but more commonly occur in a regular pattern related to the size and timing of the levodopa dosage. Theories as to their cause have emphasised both the progression of the underlying Parkinson's disease and the possibility of a late side-effect of levodopa...
2 Terminology of “on-off” effects Motor symptoms have dominated much of the research on PD, so the “on-off” effects from levodopa that Marsden and his contemporaries described are now often referred to as motor fluctuations. Motor fluctuations, “Offs”, and dyskinesias are collectively know...
Since the publication of the review by Barger on “The Alkaloids of Ergot” (1938), the study of the effects of ergot alkaloids on the central nervous system has changed its focus from the mere prediction of undesirable side effects, such as emesis or...
"On-off" symptoms were found to have developed in 43 of 85 parkinsonian patients who had been treated with L-dopa for five years or more, the risk of such symptoms apparently being greater the younger the patient had been at the début of the disease and at the start of treatment...
The effect of daytime restriction of dietary protein on the nutrient intakes and efficacy of levodopa therapy in Parkinson's disease Previous controlled studies have shown that severe daytime restriction of dietary protein improves the efficacy of L-dopa and reduces response fluctuations... S Paré...
Levodopa/carbidopa intestinal gel (LCIG; carbidopa/levodopa enteral suspension) has been widely used and studied for the treatment of motor fluctuations in levodopa-responsive patients with advanced Parkinson’s disease (PD) when other treatments have not given satisfactory results. Reduction in ‘off’...