Recent data have suggested that levodopa can either slow down the progression of Parkinson disease and/or have increased benefits even after drug administration has stopped. A common off-label use for levodopa is restless leg syndrome and periodic limb movement in sleep (PLMS). Levodopa has been ...
Although levodopa has provided a major advance in the treatment of parkinsonism, its maximum benefits have not yet been realised, in part because of its complicated pharmacokinetics. This review summarises that available pharmacokinetic data involving levodopa, especially as it relates to therapeutic ...
Learn about DUOPA™ (carbidopa/levodopa), a treatment for motor fluctuations in advanced Parkinson's disease, as well as benefits and risks.
Recent research indicated that L-DOPA/carbidopa treatment sustained long-term benefits in only 20% of patients after 2 years, while >75% of these patients experienced serious adverse events [28,32]. 2.3. The BBB To reduce side effects and improve patient compliance, increased L-DOPA ...
A worldwide yearly survey of new data in adverse drug reactions and interactions Levodopa[SED-15, 2039; SEDA-32, 285; SEDA-33, 320; SEDA-34, 242] Systemic reviewsThe comparative benefits and risks of adjuvant drugs in the treatment ofParkinson's diseasewith motor complications have been evalu...
Use caution in nursing women.Consider known benefits of breast-feeding along with mother's clinical need for the drug and any potential adverse effects on the infant from drug or underlying maternal condition. Pediatric Use Safety and efficacy not established in children <18 years of age. ...
A reassessment of risks and benefits of dopamine agonists in Parkinson's disease. Lancet Neurol 8: 929–937. A comprehensive review of the therapeutic benefits and adverse effects of dopamine receptor agonists as antiparkinsonian therapy. Article CAS PubMed Google Scholar Anwyl R (1999). ...
Use of carbidopa and levodopa extended-release tablets in women of childbearing potential requires that the anticipated benefits of the drug be weighed against possible hazards to mother and child. Nursing Mothers Levodopa has been detected in human milk. Caution should be exercised when carbidopa and...
Benefits of COMT inhibitors in levodopa-treated parkinsonian patients: results of clinical trials Neurology, 55 (11 Suppl. 4) (2000), pp. S42-45 (discussion S46–50) View in ScopusGoogle Scholar [12] J.T. Hutton, J.L. Morris, G.C. Roman, S.C. Imke, J.W. Elias Treatment of chron...
Another formulation (Example 2) with dissolution properties intermediate to those of No. 2 and No. 3 has also been developed. This formulation will provide nighttime benefits in severe patients over those seen with No. 3 <- Previous Patent (HMG-COA reductase in...)|Next Patent ((2,2-bis...