the beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with SINEMET should be carefully observed for loss of therapeutic response. Use
Use of carbidopa and levodopa extended-release in women of childbearing potential requires that the anticipated benefits of the drug be weighed against possible hazards to mother and child. Nursing Mothers Levodopa has been detected in human milk. Caution should be exercised when carbidopa and ...
Use of carbidopa and levodopa tablets in women of childbearing potential requires that the anticipated benefits of the drug be weighed against possible hazards to mother and child. Nursing Mothers Levodopa has been detected in human milk. Caution should be exercised when carbidopa and levodopa tablets...
There are no human studies that have examined the effects of Sinemet on a fetus. In prescribing Sinemet for a pregnant woman, the treating physician must weigh the potential risks to the fetus against the potential benefits to the mother. Levodopa is distributed intobreast milk. It also may in...
The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for CREXONT and any potential adverse effects on the breastfed infant from CREXONT or from the underlying maternal condition. ...
Recent data have suggested that levodopa can either slow down the progression of Parkinson disease and/or have increased benefits even after drug administration has stopped. A common off-label use for levodopa is restless leg syndrome and periodic limb movement in sleep (PLMS). Levodopa has been ...
Weigh risks versus benefits in women of childbearing potential.LactationLevodopa is distributed into human milk; caution advised. Carbidopa is distributed into milk in rats; not known whether carbidopa is distributed into human milk.Use caution in nursing women. Consider known benefits of breast-...
Impulsive disorders as screened with the Modified Minnesota Impulsive Disorders Interview were reported in few patients. Discussion In this phase 3 study, once-daily treatment with opicapone was well tolerated and was associated with significant therapeutic benefits in patients with PD who experienced ...
enters the fetus, and is metabolized. Carbidopa concentrations in fetal tissue appeared to be minimal. Use of carbidopa and levodopa extended-release tablets in women of childbearing potential requires that the anticipated benefits of the drug be weighed against possible hazards to mother and child. ...
Direct head-to-head randomized clinical trials are needed for reliable assessment of the comparative clinical benefits and cost-effectiveness of different adjuvant therapies; however, we have not identified any clinical trials comparing modern agents. Hence, it is unclear which class of drug is ...