In conclusion, effectiveness and efficacy outcomes between once- and twice-daily dosing for risperidone and olanzapine were not significantly different. However, in view of the lower mean dose and better side effect profile, it is advisable to adhere to a once-daily dosing regimen, especially in ...
Charcoal, however, may be useful in treating olanzapine overdose as peak olanzapine levels are not typically obtained until about 6 hours after dosing. Tobacco smoking Increases the clearance of olanzapine. Carbamazepine 200 mg twice daily of carbamazepine increases the clearance of olanzapine by ...
Both medications can treat several symptoms with a low risk for drug-drug interactions and with only once- or twice-daily dosing. Drug side effects are low, compared with more conventionally used agents. The pharmacokinetics and pharmacodynamics of both agents are unique and explain many of the ...
ZYPREXA And Fluoxetine In Combination: Dosing In Special Populations The starting dose of oral olanzapine 2.5-5 mg with fluoxetine 20 mg should be used for patients with a predisposition tohypotensivereactions, patientswith hepatic impairment, or patients who exhibit a combination of factors that may ...
Olanzapine displays linear kinetics over the clinical dosing range. Its half-life ranges from 21 to 54 hours (5th to 95th percentile; mean of 30 hr), and apparent plasma clearance ranges from 12 to 47 L/hr (5th to 95th percentile; mean of 25 L/hr). Administration of olanzapine once da...
the safety of total daily doses greater than 30 mg, or 10 mginjections given more frequently than 2 hours after the initial dose, and 4 hours after the second dose have not been evaluated in clinical trials. Maximal dosing of intramuscular olanzapine (e.g., 3 doses of 10 mg administered...
Steady-state concentrations achieved after approximately 7 days of continuous oral dosing and are approximately twice those observed following single-dose administration.Exhibits linear and dose-proportional pharmacokinetics when given orally within the clinical dosage range.Conventional and orally disintegrating ...
Using normative data on olanzapine (Arava- giri et al. 1996; Eli Lilly and Company 1999), we have esti- mated that the concentration of free olanzapine in blood plasma is approximately given by 0.5 nM/(mg/dy) at steady-state with daily dosing Further, assuming the free concentration of ...
Compared with placebo, the mortality rate of patients treated with olanzapine increased by twice (3.5% and 1.5% respectively). However, the incidence of death was not positively correlated with the dose of olanzapine (average daily dose of 4.4mg) or the treatment period. Ris...
The review and comparison were restricted to studies conducted at the same time, that is, after introduction of non-clozapine SGAs, to reduce a potentially confounding cohort effect by studies conducted at different times, in different populations, and with different prevailing dosing and treatment ...