今天给各位翻译的是2012年《CELL》期刊文章:TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends。 摘要 癌细胞和干细胞中的端粒合成涉及端粒酶向Cajal体的运输,端粒酶被认为通过与端粒结合蛋白的相互作用而被募集到端粒上。在这里,我们表明端粒结合蛋白TPP1的OB-fold结构域通...
We overexpressed the TPP1 OB domain (TPP1-OB) by lentivirus infection in lung cancer cells. Telomere length was examined by Southern blot analysis of terminal restriction fragments. The effects of TPP1-OB on cell proliferation, the cell cycle, apoptosis, chemosensitivity, and tumor growth were ...
OB-fold domain 专利名称：OB-fold domain 发明人：アーカス， ビックリー ローレンス,スティームソ ン， ジョン デュランド,ベーク， マティアス 申请号：JP2009511976 申请日：20070525 公开号：JP2009539346A 公开日：20091119 专利内容由知识产权出版社提供 专利附图：摘要： As used herein, a ...
The C-terminal soluble domain of stomatin operon partner protein (sTOPP) of the hyperthermophilic archaeon Pyrococcus horikoshii has an oligonucleotide bin... H Yokoyama,E Matsui,K Hiramoto,... - 《Biochimie》 被引量: 1发表: 2013年 Using dynamics-based comparisons to predict nucleic acid binding...
Our analysis of Est3 may be instructive in generating comparable missense mutations on the surface of the OB-fold domain of TPP1. This is a preview of subscription content, access via your institution Access options Subscription info for Chinese customers We have a dedicated website for our ...
(Supplementary Figs.3a,4a), suggesting that FAM35A may be recruited to DNA damage sites by two different mechanisms: the majority of FAM35A may be recruited by its interaction with REV7 through the RBD domain; whereas the minority of FAM35A may be through its OB-folds domain-mediated ...
BLAP18/RMI2 contains a putative OB-fold domain, and several lines of evidence suggest that it is essential for BTB complex function. First, the majority of BLAP18/RMI2 exists in complex with Topo IIIalpha and BLAP75/RMI1. Second, depletion of BLAP18/RMI2 results in the destabilization ...
The OB-fold domain is a compact structural motif frequently used for nucleic acid recognition. Structural comparison of all OB-fold/nucleic acid complexes ... DL Theobald,Mitton-Fry, Rachel M.,DS Wuttke - 《Annu Rev Biophys Biomol Struct》 被引量: 743发表: 2003年 ...
The OB-fold RPA70A domain of the human replication protein A also caused a significant amount of base unstacking at various locations within the DNA binding site as evidenced by steady-state fluorescence titration measurements using 2AP-labeled 5-mer DNAs. These solution studies support the ...
a Domain organization of Trbp111 and related OB-fold containing proteins. AIMP1: aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1, tRip: tRNA-import protein, TyrRS: Tyrosyl-tRNA synthetase. “M” denotes the middle domain. M1 and M2 are two sub-regions of Arc1p middle dom...