a Domain organization of Trbp111 and related OB-fold containing proteins. AIMP1: aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1, tRip: tRNA-import protein, TyrRS: Tyrosyl-tRNA synthetase. “M” denotes the middle domain. M1 and M2 are two sub-regions of Arc1p middle dom...
Here we show that Verrocchio (Ver), an oligonucleotide/oligosaccharide-binding (OB) fold-containing protein related to Rpa2/Stn1, interacts physically with HOAP and Moi, is enriched only at telomeres, and prevents telomere fusion. These results indicate that Ver is a new terminin component; we...
The antifungal protein AFP of Aspergillus giganteus is an oligonucleotide/oligosaccharide binding (OB) fold-containing protein that produces condensation o... The antifungal protein AFP is a small polypeptide of 51 amino acid residues secreted by Aspergillus giganteus. Its potent activity against phyto...
A recombinant construct containing the SMIs is highly specific for the RPA protein-DNA interaction DBD-A/B of RPA has been expressed, purified, and shown and does not inhibit the interaction between ssDNA and to be sufficient to bind DNA [9]. other OB-fold-containing proteins. The ...
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The predicted protein has 501 amino acids with an N-terminal region (amino acids 1–147) that is highly conserved among other species (Fig. 1B,C). A domain analysis revealed the presence of one OB fold that corre- sponds to OB1 (Fig. 1D). Although both OB folds of the human ...
N-terminal domain of apolipoprotein B has structural homology to lipovitellin and microsomal triglyceride transfer protein: a “lipid pocket” model for self-assembly of apoB-containing lipoprotein particles J. Lipid Res., 40 (1999), pp. 1401-1416 View PDFView articleView in ScopusGoogle Scholar...
FAM35A may bind ssDNA and protect broken DNA ends. We expressed and purified a recombinant protein containing all three OB-fold domains (381–904 aa) fused to the maltose-binding protein (MBP-FAM35A_C; Supplementary Fig.2a, b). Gel-shift assay showed that MBP-FAM35A_C bound a long ...
2003. Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein. EMBO J. 22:2561-2570.Kerr, I.D., et al., Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein. Embo J, ...
The invention relates to a topical composition containing a variant of an OB-fold protein, and also to the process for preparing the same.