A cell culture study suggests that meta aminomethyl-substituted O6-benzylguanine (BG) may be useful for overcoming the resistance of tumors to alkylating chemotherapeutics. Further details on the research, next steps and licensing status are discussed in the article....
This manuscript addresses the role of O6-methylguanine-DNA methyltransferase (MGMT) as a biomarker in the oncogenesis of cancer and the opportunity of turning this gene into a drugable target in neuroendocrine tumours of the lung. Studies in brain tumours conclude that MGMT promoter methylation is ...
螖-O6-Methylguanine-DNA methyltransferase gene transfer for O6-benzylguanine and N,N'-bis(2-chloroethyl)-N-nitrosourea resistance, and use in protection of hematopoietic progenitors in chemotherapy.Gerson, Stanton LDavis, Brian MKoc, Omer N
Why does O6-methylguanine-DNA methyltransferase (MGMT), an indispensable DNA repair enzyme, have a mechanism which seems to run counter to its importance? This enzyme is key to the removal of detrimental alkyl adducts from guanine bases. Although the mechanism is well known, an unusual feature ...
提供的O6-甲基鸟嘌呤-DNA-甲基转移酶MGMT(人源重组蛋白)(100 ug)产品形式为:50 mM Tris, pH 8.0, 150 mM sodium chloride, 10% glycerol 产品形式 O6-methylguanine-DNA Methyltransferase ��MGMT�� is a DNA repair enzyme responsible for demethylating O6-methylguanine ��O6-mG��. Th...
BMC Cancer 2010, 10:48 http://www.biomedcentral.com/1471-2407/10/48 TECHNICAL ADVANCE Open Access Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference Luca ...
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that transfers methyl and alkyl lesions from the O6 position of guanine to a cysteine in its structure. The ability of MGMT to also remove precytotoxic O6-alkylguanine lesions induced by chemotherapeutic chloroethylnitrosoureas has...
O~6-甲基鸟嘌呤-DNA甲基转移酶 1. Expression of O~6-methylguanine-DNA methyltransferase in transitional cell carcinoma of the bladder and its clinical significance; O~6-甲基鸟嘌呤-DNA甲基转移酶在膀胱移行细胞癌中的表达及临床意义 更多例句>> 5) O(6)-methylguanine-DNA methyltransferase O(6)-甲...
O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells. J Neurochem 2006;96:766-76.Hermisson, M, Klumpp, A, Wick, W, Wischhusen, J, Nagel, G, Roos, W et al. (2006). O6-methylguanine DNA methyltransferase and p53 status predict...
1) O6-Methylguanine-DNA Methyltransferase O6-甲基鸟嘌呤DNA甲基转移酶1. Ki-67 antigen, an indicator of tumor cell proliferation, is correlated with glioma grading; and O6-Methylguanine-DNA Methyltransferase(MGMT), a DNA repair protein, contributes tumor resistance to chemotherapy. 背景与目的:胶质母...