O6-Methylguanine-DNA methyltransferaseNeuroendocrine tumors (NETs) are rare, but their incidence is rising. Alkylating agents (ALKY), temozolomide and streptozotocin, are the main chemotherapies used for advance
amplifications of fibroblast growth factor 1 (FGFR1), silencing of the tumour suppressor Rb gene, mutation of the TP53 gene mutations or an aberrant expression of genes implicated in DNA damage repair, among which the O6-methylguanine methyltransferase (MGMT) gene, responsible for the repair of DN...
提供的O6-甲基鸟嘌呤-DNA-甲基转移酶MGMT(人源重组蛋白)(100 ug)产品形式为:50 mM Tris, pH 8.0, 150 mM sodium chloride, 10% glycerol 产品形式 O6-methylguanine-DNA Methyltransferase ��MGMT�� is a DNA repair enzyme responsible for demethylating O6-methylguanine ��O6-mG��. Th...
英文别名: MGMT (O6-Methylguanine DNA Methyltransferase)中文名: 中文别名: CBNumber: CB05287945 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 7 MGMT (O6-Methylguanine DNA Methyltransferase)化学性质 安全信息MGMT (O6-Methylguanine DNA Methyltransferase)性质、用途与生产工艺 MGMT (...
O 6-methylguanine-DNA methyltransferase (MGMT) is one of the DNA repair enzymes in mammals. We previously screened the variant alleles for the MGMT gene in the general population, and found three variants (V1, V2, V3), two of which caused amino acid substitutions (Leu84Phe for V1, and ...
O6-methylguanine DNA methyltransferase (MGMT) is a DNA repair enzyme attributed a role in cancer cell resistance to O6-alkylating agent-based chemotherapy. Using a panel of 12 human glioma cell lines, we here defined the sensitivity to TMZ in acute cytotoxicity and clonogenic survival assays in ...
1) O6-Methylguanine-DNA Methyltransferase O6-甲基鸟嘌呤DNA甲基转移酶1. Ki-67 antigen, an indicator of tumor cell proliferation, is correlated with glioma grading; and O6-Methylguanine-DNA Methyltransferase(MGMT), a DNA repair protein, contributes tumor resistance to chemotherapy. 背景与目的:胶质母...
6) O(6)-methylguanine-DNA methyltransferase O(6)-甲基鸟嘌呤DNA甲基转移酶补充资料:2-乙酰基-9-{[2-(乙酰氧基)乙氧基]甲基}鸟嘌呤 分子式:C12H15N5O5分子量:309.28CAS号:75128-73-3性质:暂无制备方法:暂无用途:开环鸟嘌呤(阿昔洛韦)的中间体。 说明:补充资料仅用于学习参考,请勿用于其它任何用途。
Why does O6-methylguanine-DNA methyltransferase (MGMT), an indispensable DNA repair enzyme, have a mechanism which seems to run counter to its importance? This enzyme is key to the removal of detrimental alkyl adducts from guanine bases. Although the mechanism is well known, an unusual feature ...
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that transfers methyl and alkyl lesions from the O6 position of guanine to a cysteine in its structure. The ability of MGMT to also remove precytotoxic O6-alkylguanine lesions induced by chemotherapeutic chloroethylnitrosoureas has...