O6甲基鸟嘌呤DNA甲基转移酶(O6-methylguanine-DNA methyltransferase,MGMT)是一种重要的DNA修复酶,它可以修复DNA中的O6-甲基鸟嘌呤(O6-methylguanine)损伤。O6-甲基鸟嘌呤是一种常见的DNA损伤,它可以由外源的致癌物质(如致癌药物)或内源的氧化应激产生。O6-甲基鸟嘌呤损伤可以导致DNA的结构变异,从而导致基因突变,进而导...
甲基鸟嘌呤-DNA甲基转移酶(Methylguanine-DNA Methyltransferase,简称MGMT)是一种酶类蛋白质,它可以将DNA中的O6-甲基鸟嘌呤修复为未经甲基化的鸟嘌呤。它主要通过转移O6-甲基鸟嘌呤中的甲基基团,使其与其它氨基氧化物发生共价结合,最终达到DNA修复的目的。这样可以防止O6-甲基鸟嘌呤在细胞分裂时不恰当地复制成对应的O6...
This manuscript addresses the role of O6-methylguanine-DNA methyltransferase (MGMT) as a biomarker in the oncogenesis of cancer and the opportunity of turning this gene into a drugable target in neuroendocrine tumours of the lung. Studies in brain tumours conclude that MGMT promoter methylation is ...
O6-methylguanine-DNA Methyltransferase (human recombinant)(100 ug) 供应商 Cayman Chemical 产品货号 11176-100 产品报价 ￥询价/100ug 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868. ...
O-6-methylguanine-DNA methyltransferase(MGMT)O-6-甲基鸟嘌呤-DNA-甲基转移酶:是广泛存在于细菌到哺乳动物机体中的一种独特DNA修复酶,MGMT是一种DNA修复酶,是突变和癌变的抑制因子。它对烷化剂导致的DNA损伤有修复作用。MGMT是突变和癌基因的抑制因子。研究表明MGMT水平与恶性肿瘤的发生、进展、浸润、预后及治疗有...
对于接受放化疗的新诊断的GBM患者,MGMT状态作为预后生物标志物的最佳评估需要同时测定启动子甲基化和IHC蛋白表达。 Reference Combined analysis ofO6-methylguanineDNA methyltransferase protein expressionand promoter methylation provides optimi...
提供的O6-甲基鸟嘌呤-DNA-甲基转移酶MGMT(人源重组蛋白)(25 ug)产品形式为:50 mM Tris, pH 8.0, 150 mM sodium chloride, 10% glycerol产品形式 O6-methylguanine-DNA Methyltransferase ��MGMT�� is a DNA repair enzyme responsible for demethylating O6-methylguanine ��O6-mG��. The...
甲基转移酶(O6?methylguanine?DNA methyltransferase,MGMT)是一种高效的DNA直接修复酶,能修复 DNA序列中的6?氧?甲基鸟嘌呤(O6?methylguanine,O6?mG)损伤, 是人类细胞中迄今发现的唯一一种修复该损伤的甲基转移酶。 1MGMT概述 1.1基因结构人类MGMT(hMGMT)基因定位于10q26,全长 170kb,含5个外显子,4个内含子。其...
中文名称O6甲基鸟嘌呤DNA甲基转移酶抗体 别名6 O methylguanine DNA methyltransferase; Agat; AGT; AI267024; EC 2.1.1.63; Methylated DNA protein cysteine methyltransferase; Methylguanine DNA methyltransferase; MGC107020; MGMT: 浓度1mg/1ml 规格0.1ml/100μg 0.2ml/200μg ...
O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells. J Neurochem. 2006; 96 (3): 766-776.Hermisson M, Klumpp A, Wick W, et al: O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant...