Advances and Applications in Bioinformatics and Chemistry Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH O-GlcNAcylation Prediction: An Unattained Objective Theo Mauri 1 Laurence Menu- Bouaouiche 2 Muriel Bardor 2 Tony Lefebvre 1 Marc F Lens...
In particular, O-GlcNAcylation has the potential to be an important target for therapeutics, but OGlcNAcylationsites are not known.Network Daily News
当 GSDMD 能够正常进行 O-GlcNAc 修饰(GD-WT)时,TMG 可增加 GSDMD 的 O-GlcNAcylation,从而减少 Caspase-4 和 GSDMD 之间的结合以及 GSDMD 的裂解(第 2 行与第 1 行比较);GSDMD S338A 突变质粒可增加 Caspase-4 和 GSDMD 之间的 O-GlcNAcylation,从而减少 Caspase-4 和 GSDMD 之间的结合以及 GSDMD 的裂解...
Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system The posttranslational modification of serine and threonine residues of nuclear and cytoplasmic proteins by the O-linked attachment of the monosaccharide be... B Laczy,BG Hill,W Kai,... - 《Am J Physiol Heart Circ ...
Prediction of O-Glycosylation Sites in Protein Sequences Using Meta-predition Approach Background: O -GlcNAcylation is an essential post-translational modification (PTM) in mammalian cells. It consists in the addition of a N-acetylglucosamine... YH Chen 被引量: 0发表: 2015年 Dominant orientation...
O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is a critical post-translational modification (PTM) of cytoplasmic and nuclear proteins. O-GlcNAcylation levels are regulated by the activity of two enzymes, O-GlcNAc transferase (OGT) and O‑GlcNAcase (OGA). While OG...
Shanghai Tenth People's Hospital, Tongji University of Medicine, Shanghai, 200072, People's Republic of China *These authors contributed equally to this work Objective: NUSAPl and O-GlcNAcylation were reported to be hyper-activated in many kinds of cancers and involved in the advanced progression...
(Fig.1b; Supplementary Fig.1b)31,39. Importantly, we observed CTCF can also be O-GlcNAcylated and arginine methylated, which has not been reported previously (Fig.1b). To further confirm the results, purified CTCF proteins were enriched with the antibodies of O-GlcNAcylation and arginine ...
These studies have demonstrated an important role of protein O-GlcNAcylation in regulating TRAIL resistance of pancreatic cancer cells; and uncovered the contribution of O-GlcNAcylation to DR5 oligomerization and thus mediating DR-inducing signaling. 摘要 TRAIL激活疗法有望治疗多种癌症,包括胰腺癌,一种...
(e) Prediction of the O-GlcNAcylation site in TaGRP2 by YinOYang online prediction tool http://www.cbs.dtu.dk/services/YinOYang/. (f) Point mutation of Thr17 dramatically reduced the level of O-GlcNAcylation of TaGRP2. specific attachment of azido-modified galactose (GalNAz) to O-GlcNAc ...