On the independent test set,Captoroutperformed the existing O-glycosylation tool, suggesting thatCaptorcould provide more instructive guidance for further experimental research on O-glycosylation. The source code and datasets are available at https://github.com/YanZhu06/Captor/....
O-glycosylation is a protein posttranslational modification important in regulating almost all cells. It is related to a large number of physiological and pathological phenomena. Recognizing O-glycosylation sites is the key to further investigating the molecular mechanism of protein posttranslational modific...
Factors analysis of protein O-glycosylation site prediction. Comput Biol Chem. 2017;71:258–63. 112. Hassan H, Badr A, Abdelhalim MB. Prediction of O-glycosylation Sites Using Random Forest and GA-Tuned PSO Technique. Bioinform Biol Insights. 2015; 9:103–9. 113. Chen Y, Zhou W, Wang...
The O-glycosylation sites were found to cluster and to have a high abundance in the N-terminal part of the protein. The sites were also found to have an increased preference for three different classes of beta-turns. No simple consensus-like rule could be deduced for the complex ...
Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of O-linked glycosylation of proteins. Here, we show that ablation of Cos
Site-specific glycosylation analysis is key to investigate structure-function relationships of glycoproteins, e.g. in the context of antigenicity and disease progression. The analysis, though, is quite challenging and time consuming, in particular for O-glycosylated proteins. In consequence, despite ...
is one of the major challenges for the field; however, we did demonstrate high glycosylation occupancy for proNPY when expressed in two different cell lines. We expect that future studies will reveal how this reflects the O-glycan occupancy found in circulation or at the local site of ...
O-linked glycosylation is an important post-translational modification of mucin-type protein, changes to which are important biomarkers of cancer. For this study of the enzymes ofO-glycosylation, we developed a shorthand notation for representing GalNAc-linked oligosaccharides, a method for their graphic...
Unlike N-glycosylation for which the consensus site is well known (N-X-S/T/C with X any residue except proline) and conserved, no specific pattern is currently known for the O-GlcNAcylation. Therefore, developing efficient prediction tools represent a challenge. Few prediction tools such as ...
Gupta R, Brunak S: Prediction of glycosylation across the human proteome and the correlation to protein function. Pac Symp Biocomput. 2002, p310-22. Google Scholar Li S, Liu B, Zeng R, Cai Y, Li Y: Predicting O-glycosylation sites in mammalian proteins by using SVMs. Comput Biol Chem...