近日，南方医科大学基础医学院神经生物学教研室曹雄课题组在The journal of clinical investigation杂志上在线发表了题为O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission 的论文。该论文揭示了前额叶皮层（mPFC）星型胶质细胞OGT调节谷氨酸转运蛋...
近日,南方医科大学基础医学院神经生物学教研室曹雄课题组在The journal of clinical investigation杂志上在线发表了题为O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission的论文。该论文揭示了前额叶皮层(mPFC)星型胶质细胞OGT调节谷氨酸转运蛋白(G...
O-GlcNAc修饰是一类非经典的蛋白糖基化,与多糖链直接修饰在细胞膜表面和分泌蛋白上的经典糖基化不同,O-GlcNAc糖基化是单个GlcNAc通过β糖苷键连接于胞内蛋白底物的丝氨酸(serine, Ser)和苏氨酸(threonine, Thr)残基上[3,4]。这种动态可逆的糖基化只由两个酶负责...
O-GlcNAc transferase and Aurora kinase B both also interact with Protein Phosphatase 1 (PP1c). When PP1c is affinity purified from mitotic cells, Aurora kinase B, O-GlcNAc transferase, and O-GlcNAcase, the enzyme responsible with the removal of the moiety, all co-purify with PP1. These ...
This protein modification is mainly governed by a pair of enzymes: O-GlcNAc transferase (OGT) adds the N-acetylglucosamine moiety to acceptor proteins, and O-GlcNAcase (OGA) hydrolyses the sugar moiety from protein acceptors. Ir...
A single pair of enzymes — O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) — controls the dynamic cycling of this PTM. Potential mechanisms that enable a single OGT enzyme to recognize hundreds of protein substrates include substrate-specific interactions with the tetratricopeptide repeat (TPR)...
抗体名:O位N-乙酰葡萄糖胺OGT抗体O-GlcNActransferase免疫标记 浓度:1mg/ml % 靶点:细胞核,细胞膜等 宿主:Rabbit、mouse 用途:交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 ...
O-GlcNAc糖基化修饰是一种重要的蛋白质翻译后修饰。这种修饰是将N-乙酰葡萄糖胺(GlcNAc)转移到蛋白质的丝氨酸(Serine)或苏氨酸(Threonine)残基上,对多种生物学通路产生影响,例如骨髓分化、细胞周期调控、自噬过程以及蛋白质的活性调控等。O-GlcNAc糖基化修饰由O-GlcNAc转移酶(OGT)介导。OGT过表达导致的O-GlcNAcylati...
O-GlcNAc糖基化修饰由一对循环酶O-GlcNAc糖基转移酶(O-GlcNAc transferase,OGT)和O-GlcNAc糖苷水解酶(O-GlcNAcase,OGA)的催化来特异性调控。OGT蛋白在人体内有3个亚型:核-浆OGT(nuclear cytoplasmicO-GlcNAc transferase,nc-OGT)、线粒体OGT(mitochondrialO-GlcNAc transferase,m-OGT)和小片段OGT(short isoformO-...
O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by two highly conserved enzymes, i.e. O-GlcNAc transferase (OGT) and protein O-GlcNAcase (OGA). Protein O-GlcN