Nucleotide sugar transporters (NSTs) are crucial components in the synthesis of glycoconjugates (Fig. 1) ( Caffaro and Hirschberg 2006 ). Glycosylation can be performed by various types of glycosyltransferase in the lumens of the endoplasmic reticulum and the Golgi apparatus. All glycosyltransferases ...
In humans, the mutation of a GDP-fucose transporter is responsible for an impaired immune response as well as retarded growth. These results suggest that, even though there appear to be a fair number of genes encoding for NSTs, they are not functionally redundant and seem to play specific ...
Here we present the crystal structure of an NST, the GDP-mannose transporter Vrg4, in both the substrate-free and the bound states. A hitherto unobserved requirement of short-chain lipids in activating the transporter supports a model for regulation within the highly dynamic membranes of the ...
SLC35A1 CMP-Sia transporter, (CST) CMP-Sia Exclusively Golgi 337 P78382 SLC35A2UGALTUGTUGTL UDP-Galactose translocator, UGP-Gal Tr, (UGT). UDP-Gal; UDP-GlcNAc Golgi and/or ER 396 P78381 SLC35A3 UDP-N-acetylglucosamine transporter, UDP-GlcNAc transporter, Golgi UDP-GlcNAc Tr, (NGT) UDP...
This review briefly summarizes the present status of the field of nucleotide sugar transporter research, and also presents an outlook of the study in this field. 展开 关键词: glycoconjugate Golgi apparatus modulation of glycosylation molecular cloning nucleotide sugar transporter ...
In humans, the mutation of a GDP-fucose transporter is responsible for an impaired immune response as well as retarded growth. These results suggest that, even though there appear to be a fair number of genes encoding for NSTs, they are not functionally redundant and seem to play specific ...
and branches within families./p pResults/p pWe present evidence that the triose-phosphate transporters, domain unknown function 914, uracil-diphosphate glucose-N-acetylglucosamine, and nucleotide sugar transporter families have evolved from a domain duplication event before the radiation of itViridiplantae...
10). MDCK-RCAr mutant lacks the UDP-galactose transporter because of the nucleotide substitution in the SLC35A2 gene [27]. To determine whether the observed mutually exclusive overexpression of A3 or A4 depends on A2 we decided to transfect MDCK with the pVitro-HA-A4/c-myc-A3 plasmid. ...
Because Entamoeba has this QC system while Giardia does not, we hypothesized that transfected Giardia might be used to identify the UDP-Glc transporter of Entamoeba. Here we show Giardia membranes transport UDP-GlcNAc and have apyrases, which hydrolyze nucleoside-diphosphates to make the antiporter ...
Nucleotide sugars are the activated form of monosaccharides used by glycosyltransferases during glycosylation. In eukaryotes the SLC35 family of solute carriers are responsible for their selective uptake into the Endoplasmic Reticulum or Golgi apparatus. The structure of the yeast GDP-mannose transporter, ...