Nucleotide sugar transporters (NSTs) are crucial components in the synthesis of glycoconjugates (Fig. 1) ( Caffaro and Hirschberg 2006 ). Glycosylation can be performed by various types of glycosyltransferase in the lumens of the endoplasmic reticulum and the Golgi apparatus. All glycosyltransferases ...
A novel human nucleotide sugar transporter (NST) which transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) has been ... M Muraoka,M Kawakita,N Ishida - 《Febs Letters》 被引量: 206发表: 2001年 Growth Regulators and the Control of Nucleotide Sugar Flu...
Previously, subcellular localization of nucleotide sugar transporters has been investigated many times. It has been determined that the CMP-sialic acid transporter, the UDP-N-acetylglucosamine transporter, the GDP-fucose transporter, the first splice variant of the UDP-galactose transporter (A2-Golgi) ...
Multidrug resistance (MDR) is the major cause, by which cancer cells expel the drugs out, developing a challenge against the current chemotherapeutic drugs regime. This mechanism is attributed to the over expression of ABC transporters like MRP1 on the s
BoFCC221A41U3RACS5SDXL14CPDSAE11SO3PHL7MX5SXMNSD34CrAT74RPDPF0159PDFTC2D4FRIRfMS14SDGPGN1P1P2AMBTIGM2KHRC3A4PAT1O9P1DMUCCDoSRM1F8E5BNCISLYIZTBY2CTARKA4ORRPMPNDI78PC22KHBAEKH5r2M92BMMMPFI43VMXCAS2RSPPC1MNDCAYIFMNTSSSfL2DLNP0KT1O51PDE0PA94RoLDSL11MDEOCNCSIDSALA1TRYNNCEN1ERED...
Previously, we characterized Arabidopsis thaliana GONST1 and showed that it was a nucleotide sugar transporter which provides GDP﹎annose for GIPC glycosylation. gonst1 has a severe growth phenotype, as well as a constitutive defense response. Here, we characterize a mutant in GONST1's closest ...
Nucleotide sugar transporters, CMP-sialic acid transporter, Golgi apparatus, Endoplasmic reticulum, SLC35The covalent attachment of sugars to growing glycan chains is heavily reliant on a specific family of solute transporters (SLC35), the nucleotide sugar transporters (NSTs) that connect the synthesis...
Nucleotide-sugarNucleotide-sugar transporters (NSTsPAPST transporters (PAPSTsRNA interference (RNAiSolute carrier 35 (SLC35SulfationGlycosylation and sulfation are important posttranslational modifications of proteins and are performed in the lumens of the endoplasmic reticulum (ER) or the Golgi apparatus ...
Map-based cloning revealed that all of the observed mutant phenotypes result from a missense mutation in a putative NST gene, Oryza sativa Nucleotide Sugar Transporter1 (OsNST1). OsNST1 was identified as a Golgi-localized transporter by analysis of a fluorescence-tagged OsNST1 expressed in rice...
Toxoplasma TgNST1 is a nucleotide-sugar transporter that transports UDP-GlcNAc and UDP-GalNac.Carolina E. CaffaroAnita A. KoshyLi LiuGusti M. ZeinerCarlos B. HirschbergJohn C. Boothroyd