Nucleotide sugar transporters (NSTs) are crucial components in the synthesis of glycoconjugates (Fig. 1) ( Caffaro and Hirschberg 2006 ). Glycosylation can be performed by various types of glycosyltransferase in the lumens of the endoplasmic reticulum and the Golgi apparatus. All glycosyltransferases ...
SLC35A3 UDP-N-acetylglucosamine transporter, UDP-GlcNAc transporter, Golgi UDP-GlcNAc Tr, (NGT) UDP-GlcNAc Predominantly Golgi 325 Q9Y2D2 SLC35A4 Probable UDP-sugar transporter MGC2541 Putative UDP-Gal Predominantly Golgi 324 Q96G79 SLC35A5(ORF) UNQ164(OFR) PRO190 Probable UDP-sugar transport...
This review briefly summarizes the present status of the field of nucleotide sugar transporter research, and also presents an outlook of the study in this field. 展开 关键词: glycoconjugate Golgi apparatus modulation of glycosylation molecular cloning nucleotide sugar transporter ...
In humans, the mutation of a GDP-fucose transporter is responsible for an impaired immune response as well as retarded growth. These results suggest that, even though there appear to be a fair number of genes encoding for NSTs, they are not functionally redundant and seem to play specific ...
Previously, subcellular localization of nucleotide sugar transporters has been investigated many times. It has been determined that the CMP-sialic acid transporter, the UDP-N-acetylglucosamine transporter, the GDP-fucose transporter, the first splice variant of the UDP-galactose transporter (A2-Golgi) ...
(PDB: 5OGE) now provides opportunities for structure-based drug design targeted at this class of transporter. The structure revealed specificity pockets that separate recognition of the nucleotide and sugar groups, revealing sequence motifs that appear to correlate with substrate specificity. Nevertheless...
A putative Drosophila nucleotide sugar transporter was characterized and shown to be the Drosophila homologue of the human UDP-Gal transporter (hUGT). When... H Segawa,M Kawakita,N Ishida - 《European Journal of Biochemistry》 被引量: 140发表: 2002年 Molecular Cloning and Characterization of a...
SummaryUridine 5′-diphosphate (UDP)-glucose is transported into the lumen of the endoplasmic reticulum (ER), and the Arabidopsis nucleotide sugar transporter AtUTr1 has been proposed to play a role in this process; however, different lines of evidence suggest that another transporter(s) may also...
et al. Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human. Nat. Med. 13, 1363–1367 (2007). Article CAS PubMed Google Scholar Stanley, P. Golgi glycosylation. Cold Spring Harb. Perspect. Biol. 3, a00...
Nucleotide sugar transporters have long been assumed to be antiporters that exclusively use nucleoside monophosphates as antiport substrates. Here we present evidence indicating that two other types of nucleotide sugar transporters exist that differ in their antiport substrate specificity. Biochemical ...