(57) provides a method of preparing a nucleic acid binding protein of the Cys2-His2 zinc finger class capable of binding nucleic acid quadruplet target nucleic acid sequence in (quadreplet), [Abstract] The present invention, in the method, binding to the base 4 of 4 base chain of the ...
In recent years, for genome editing, many programmable nucleic acid-binding proteins, such as the zinc-finger protein (ZFP), transcription activator-like effector (TALE) protein, and clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) protein, have been intensely charact...
a, SEPRO1-9 and their progenitor protein DHR8. SEPRO1-5 were chosen from the productive phase of the synthetic evolution cycle, SEPRO6-9 were chosen from earlier generations. SEPRO1-3 were found to bind nucleic acids. b, Comparison of nucleic acid binding SEPROs and PPRs (designated ...
Intriguing nucleic-acid-binding features of mammalian prion protein Cordeiro, "Intriguing nucleic-acid-binding features of mammalian prion protein," Trends in Biochemical Sciences, vol. 33, no. 3, pp. 132- 140, 2008... JL Silva,LMTR Lima,D Foguel,... - 《Trends in Biochemical Sciences》 ...
Protein-Nucleic Acids Interactions M. Michael Gromiha, R. Nagarajan, in Advances in Protein Chemistry and Structural Biology, 2013 2.4 Thermodynamic database for protein–nucleic acid interactions The numerical data on binding specificity of protein–DNA complexes provide information about the affinity of...
The single-stranded nucleic acid-binding protein KHSRP (KH-type splicing regulatory protein) modulates RNA life and gene expression at various levels. KHSRP controls important cellular functions as different as proliferation, differentiation, metabolism, and response to infectious agents. We summarize and...
A single-stranded nucleic acid-binding protein from Artemia salina. II. Interaction with nucleic acids. J. Biol. Chem. 255, 6473±6478... DK Marvil,L Nowak,W Szer - 《Journal of Biological Chemistry》 被引量: 52发表: 1980年 A Single-stranded Nucleic Acid-binding Protein from Artemia salin...
Protein–RNA and protein–DNA complexes play critical roles in biology. Despite considerable recent advances in protein structure prediction, the prediction of the structures of protein–nucleic acid complexes without homology to known complexes is a lar
Nucleic acid - Metabolism, Structure, Function: Replication, repair, and recombination—the three main processes of DNA metabolism—are carried out by specialized machinery within the cell. DNA must be replicated accurately in order to ensure the integri
Protein–nucleic acid interactions play key roles in many biological processes. In a large group of such events, the binding of the proteins to their respective nucleic acid counterpart affects some regulatory outcome such as transcriptional and translational regulation and protein synthesis. Activation ...