L. Urquhart, Decreased nuclear receptor activity and epigenetic modulation associates with down-regulation of hepatic drug- metabolizing enzymes in chronic kidney disease, FASEB J, 28, 5388-5397, (2014).Velenosi TJ, Feere DA, Sohi G, Hardy DB, Urquhart BL. Decreased nuclear receptor activity ...
nuclear receptor activity modulators; 4-(ethylamino)-3-{[(2Z,5Z)-5-{[methyl(phenyl)amino]methylidene}-4-oxo-3-(phenylmethyl)-1,3-thiazolidin-2-ylidene]amino}benzonitrile; diseases or disorders affected by abnormal cholesterol, triglyceride, or bile acid levelsUS 7902237 B2 Abstract Compounds...
Nuclear receptor data In this work, data is collected using a public compound repository known as NURA (NUclear Receptor Activity) database [27], which includes public information on the activity of 15,247 compounds on 11 human NRs. The database contains information of compounds collected from s...
The strategy applied successfully in identifying novel nuclear receptor ligands is based on the key principle of activity-guided purification followed by structure determination. A particular benefit of the modular structure of nuclear receptors is the ability to construct chimeras that retain the specific...
Nuclear receptor subfamily 4, group A,member 1 inhibits extrinsic apoptosis andreduces caspase-8 activity in H2O2-inducedhuman HUC-F2 fibroblastsYuri Shimizu, Reiko Miyakura, Yuzuru OtsukaGraduate School of Humanities and Sciences, Ochanomizu University, Bunkyo, Tokyo, JapanObjective: Apoptosis is ...
Our study reveals a function for the nuclear receptor RARγ as a key regulator of RIP1-initiated cell death when cIAP activity is inhibited. As RIP1-initiated cell death is a vital cellular response triggered by death factors, the engagement of this pathway is finely regulated. As shown in ...
–dependent regulation of transcription factors (nuclear receptor 4A1 [NR4A1], NR4A2, and NR4A3), RANKL, and osteoprotegerin (OPG) messenger RNA (mRNA) levels were measured in primary and SW-1353 chondrocyte cells using quantitative polymerase chain reaction and selective histamine receptor ...
ShortHeterodimerPartner(SHP)OrphanNuclearReceptor InhibitstheTranscriptionalActivityofArylHydrocarbon Receptor(AHR)/AHRNuclearTranslocator(ARNT) CarolynM.Klinge, 1 SarahC.Jernigan,KellyE.Risinger,JennieE.Lee,ValentynV.Tyulmenkov, K.CameronFalkner,andRussellA.Prough DepartmentofBiochemistryandMolecularBiology,Univer...
The possibility that interaction of the nuclear localization signal (NLS) with its pore receptor may directly stimulate nuclear envelope-associated ATPase activity and consequently provide energy for protein translocation across the pore has been studied. ATPase activity was assayed after cross-linking of...
Furthermore, glucose-dependent increases in LXR/retinoid X receptor-regulated luciferase activity driven by the ChREBPα promoter was mediated, at least in part, by O-GlcNAc transferase (OGT) signaling in Huh7 cells. Moreover, we show that LXR and OGT interact and colocalize in the nucleus ...