O’MalleyBaylor College of Medicine, Houston, TX 77030, USAReceptor or Family* Symbols Expression Major FunctionsDisease Associations Target GenesEstrogen-related receptors*ERRα/NR3B1; ERRβ/NR3B2; ERRγ/NR3B3 All major systems with specif i c isoforms showing peaks of expression in metabolic ...
Finally, increased ECS or RA activity ameliorated the reduced lipid abundance caused by peroxisome proliferator-activated receptor gamma (PPARγ) inhibition. Therefore, the ECS and RA pathway influence lipid abundance in zebrafish embryos and have an additive effect when treated simultaneously. Further...
Synthesis and structure–activity relationships of novel indazolyl glucocorticoid receptor partial agonists SAR was used to further develop an indazole class of non-steroidal glucocorticoid receptor agonists aided by a GR LBD (ligand-binding domain)-agonist co-cr... John L. Gilmore a,James E. Shepp...
aPPAR是一种核激素受体,罗格列酮与PPAR的γ异构体结合,激活该受体,增强胰岛素对肝细胞生糖的抑制作用,增强胰岛素对肌细胞摄取外周血糖的促进作用,增加外周组织葡萄糖转运体 (glucose transporter,GLUT)-1和 GLUT-4的转录和蛋白合成,增加基础葡萄糖的摄取和转运,降低其血糖水平,从而减少高血糖的毒性作用。同时罗格列酮...
Nuclear receptor data In this work, data is collected using a public compound repository known as NURA (NUclear Receptor Activity) database [27], which includes public information on the activity of 15,247 compounds on 11 human NRs. The database contains information of compounds collected from ...
ObjectiveTo elucidate histamine receptor–mediated signaling pathways, transcriptional events, and target gene expression in human cartilage.MethodsHistamine modulation of cartilage destruction was assessed by Safranin O staining and proteoglycan release. H1, H2, H3, and H4 histamine receptor–dependent regula...
Our study reveals a function for the nuclear receptor RARγ as a key regulator of RIP1-initiated cell death when cIAP activity is inhibited. As RIP1-initiated cell death is a vital cellular response triggered by death factors, the engagement of this pathway is finely regulated. As shown in ...
Identification and Characterization of Nuclear Retionic Acid-Binding Activity in Human Myeloblastic Leukemia HL-60 CellsModulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1.Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid ...
In addition, PTMs such as the addition of a Small Ubiquitin-like MOdifier peptide (SUMO), phosphorylation and ubiquitination have been also shown to be key regulators of nuclear receptor activity, including Nr4a receptors [2,[15], [16], [17]]. Modification by SUMO regulates various aspects ...
extra-nuclear activity through binding to cyclin D1 to induce cell cycle arrest [27]. Additionally, we found that INSM1 displays an extra- nuclear function through its involvement in the insulin receptor (InR)- mediated signal transduction pathway. InR-mediated signaling is important for pancreatic...