Downregulation of nuclear sex steroid receptor activity correlates with severity of alcoholic liver injury. Am J Physiol Gastrointest Liver Physiol 281: 342-349, 2001.Eagon;PK;Elm;MS;Tadic;SD;Nanji;AA.Down regulation of nuclear sex steroid receptor activity correlates with severity of alcoholic liver...
Moudgil VK.(1994). Steroid/Nuclear receptor superfamily: recent advances and relation to health and diseases. In Steroid Hormone Receptors: Basic and Clinical Aspects. Hormones in Health and Disease. Moudgil VK. (edit) Birkhauser Publish. 1994,p3-46....
Regulation of the transcriptional activity of nuclear receptors by the MEK/ERK1/2 pathway Fabien Zassadowski, ... Bruno Cassinat, in Cellular Signalling, 2012 3.1 Nuclear receptor classification Since the late 1980s, it is known that nuclear receptors are a large family of molecules with similar...
RNA aptamer has been shown to interact with estrogen receptor alpha (ERα) to inhibit its transcriptional activity in breast cancer cells [21]. The selected RNA aptamer competes with dsDNA for NF-κB binding [22]. Steroid receptor RNA activator (SRA), a long non-coding RNA, binds to ERα...
Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice Genetic disruption of the steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF)2/SRC-2 in mouse resulted in distinctive mutant... Ye, XC...
Using six ligands that bind to four different receptors in the nuclear steroid/thyroid hormone superfamily, we have examined the effects of these chemicals on induction of the cytosolic aldehyde dehydrogenase (ALDH3c) activity by 3-methylcholanthrene (3MC) in rat liver and uterus. In contrast to...
SXR forms a heterodimer with RXR that can bind to and induce transcription from response elements present in steroid-inducible cytochrome P450 genes in response to hundreds of natural and synthetic compounds with biological activity, including therapeutic steroids as well as dietary steroids and lipids....
Karmakar S, Jin Y, Nagaich AK (2013) Interaction of glucocorticoid receptor (GR) with estrogen receptor (ER) alpha and activator protein 1 (AP1) in dexamethasone-mediated interference of ERalpha activity. J Biol Chem 288:24020–24034. doi:10.1074/jbc.M113.473819 Article CAS PubMed PubMed ...
In addition, intracellular domain of DLL1 may downregulate Notch receptor activity, disrupting the formation of the Notch intracellular domain and recombination signal binding protein for immunoglobulin kappa J region (RBP-Jk) complex [69]. Recently, JAG1 intracellular domain was identified as a ...
Indeed, the androgen receptor (AR) drives the majority of prostate cancer while the estrogen receptor (ER) and progesterone receptor (PR) promote the growth of many breast cancers.41 Inhibition of nuclear hormone activity has long been a standard of care for the treatment of many metastatic ...