Steroid Hormone and Nuclear Receptor Signaling Pathways: Applications in Precision MedicineThe steroid nuclear receptor family plays an important role in cancer. The receptors upon activation exert both genomic as well as non-genomic actions resulting in growth and survival signals. Multiple co-regulators...
The gene transcription needs the participation of transcription factors such as EcR-B1, USP1 and E75B, which were initiated by 20E in the sig- nal transduction pathway, to transport into the nucleus. The evidence that the expression of 20E regulated genes decreased after the knockdown of Ha-...
The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely the last decades. In a previous clinical study of...
Estrogen signaling is mediated through two ERs, ERα and ERβ, both belonging to the NR family of transcription factors. Recent studies have demonstrated that activated ER may promote physiological functions via non-transcriptional mechanisms [12,28]. These non-genomic effects involve steroid-induced ...
Membrane-initiated estrogen receptor signaling mediates metabolic homeostasis via central activation of protein phosphatase 2A Diabetes, 67 (2018), pp. 1524-1537 CrossrefView in ScopusGoogle Scholar 36 R.D. Patten, I. Pourati, M.J. Aronovitz, et al. 17 Beta-estradiol differentially affects left...
The gene transcription needs the participation of transcription factors such as EcR-B1, USP1 and E75B, which were initiated by 20E in the signal transduction pathway, to transport into the nucleus. The evidence that the expression of 20E regulated genes decreased after the knockdown of Ha-Ntf2...
Progesterone receptor (PR) isoforms are dual functioning steroid hormone receptors, capable of activation of target gene transcription, and rapid stimulation of membrane-initiated intracellular signaling cascades. Herein we provided a retrospective of our recent work investigating the role of progestin-...
Alternative processing of α-thyroid hormone receptor (TRα, NR1A1) mRNAs gives rise to two functionally antagonistic nuclear receptors: TRα1, the α-type receptor, and TRα2, a non-hormone binding variant that is found only in mammals. TRα2 shares an
The presence of a GB, staining positive for TSPY, initiated a discussion about the karyotype of the patient. In situ hybridization and karyotyping Fluorescent in situ hybridization was performed on the gonadal tissue, (see Figure 1g) and in parallel, karyotyping of peripheral lymphocytes was ...
Estrogen signaling is mediated through two ERs, ERα and ERβ, both belonging to the NR family of transcription factors. Recent studies have demonstrated that activated ER may promote physiological functions via non-transcriptional mechanisms [12,28]. These non-genomic effects involve steroid-induced...