参考文献 JangalweS, Shultz LD, Mathew A, Brehm MA. Improved B cell development in humanized NOD-scidIL2Rγnullmice transgenically expressing human stem cellfactor,
2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24(10):1785-8 PubMed: 20686503 MGI: J:166359 品系描述: 该小鼠含有 3 个共同注射的转基因,即人白介素-3 (IL-3)、人粒细胞/巨噬细胞刺激因子 (GM-...
Thus, PDX-bearing hu-NSG-SGM3 mice might serve as a new and improved platform for preclinical immuno-oncology efficacy studies.Citation Format: Li-Chin Yao, Mingshan Cheng, Minan Wang, Jacques Banchereau, Karolina Palucka, Leonard Shultz, Carol Bult, James G. Keck. Patient-derived tumor ...
The second feature is the predisposition of NSG-SGM3 mice given these human cells to develop eosinophil hyperplasia. The third feature, secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS)–like disease, is the most pronounced in both its clinical and histopathologic ...
METHODS :We grafted human CD34 + hematopoietic stem cells into NSG-SGM3 (NSGS) mice. The hu-NSGS mice underwent total body irradiation at doses of 2, 3, and 4Gy. Tissues from the spleen, thymus, and lymph nodes of hu-NSGS mice were prepared to analyze levels of CD45 + and CD3 ...
IL‐17ANSG‐SGM3PD‐1T cellThe humanized NOD/SCID/IL‐2 receptor γ‐chainnull (NSG) mouse model has been widely used for the study of HIV pathogenesis. Here, NSG mice with transgenic expression of human stem cell factor (SCF), granulocyte–macrophage colony‐stimulating factor (GM‐CSF) ...