aureus: although they had stronger human immune cell engraftment than humanized NSG mice, particularly in the myeloid compartment, they displayed even more pronounced vulnerability to S. aureus infection. HuSGM3 mice had overall higher numbers of human T cells, B cells, neutrophils ...
参考文献 JangalweS, Shultz LD, Mathew A, Brehm MA. Improved B cell development in humanized NOD-scidIL2Rγnullmice transgenically expressing human stem cellfactor,
2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24(10):1785-8 PubMed: 20686503 MGI: J:166359 品系描述: 该小鼠含有 3 个共同注射的转基因,即人白介素-3 (IL-3)、人粒细胞/巨噬细胞刺激因子 (GM-...
2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24(10):1785-8 PubMed: 20686503 MGI: J:166359 NSG-SGM3转基因小鼠品系描述: 该小鼠含有 3 个共同注射的转基因,即人白介素-3 (IL-3)、人粒细胞/巨...
Similarly, the greatest engraftment of primary human acute myeloid leukemia samples was achieved in NSG-SGM3 mice followed by NOD/SCID-SGM3, NSG, and NOD/SCID.8 A number of mouse models genetically engineered to harbor mutations common to CMML and JMML have provided important mechanistic insights...
Thus, PDX-bearing hu-NSG-SGM3 mice might serve as a new and improved platform for preclinical immuno-oncology efficacy studies.Citation Format: Li-Chin Yao, Mingshan Cheng, Minan Wang, Jacques Banchereau, Karolina Palucka, Leonard Shultz, Carol Bult, James G. Keck. Patient-derived tumor ...
Next, to launch a CRS mouse model, FT-CAR T cells were administered into NSG-SGM3 mice engrafted with Nalm-6 cells. Mice received 1x107 FT-CAR or activated T cells intravenously. Health condition assessment and body index calculation were regularly monitored using weight, and body temperature...
Malignant pleural mesothelioma is a neoplasm that is often detected late due to nonspecific symptoms. This study utilized NSG-SGM3 mice to examine interactions between a human-derived mesothelioma reporter cell line (MZT-Luc2-mCherry) and the host's myeloid compartment. Tumor growth was assessed ...
Malignant pleural mesothelioma is a neoplasm that is often detected late due to nonspecific symptoms. This study utilized NSG-SGM3 mice to examine interactions between a human-derived mesothelioma reporter cell line (MZT-Luc2-mCherry) and the host's myeloid compartment. Tumor growth was assessed ...
IL‐17ANSG‐SGM3PD‐1T cellThe humanized NOD/SCID/IL‐2 receptor γ‐chainnull (NSG) mouse model has been widely used for the study of HIV pathogenesis. Here, NSG mice with transgenic expression of human stem cell factor (SCF), granulocyte–macrophage colony‐stimulating factor...